Interplay of Nanoparticle Properties during Endocytosis

doi:10.3390/cryst11070728

IMECH-IR > 非线性力学国家重点实验室

	Interplay of Nanoparticle Properties during Endocytosis
	Wang XH(王小环)1,2,3; Li L(李龙)1,2; Song F(宋凡)1,2,3
通讯作者	Li, Long(lilong@lnm.imech.ac.cn)
发表期刊	CRYSTALS
	2021-07-01
卷号	11 期号:7 页码:13
摘要	Nanoparticles (NPs) have been widely applied as drug carriers in drug delivery, due to their unique physical and structural properties. To achieve the drug delivery purpose, receptor-mediated endocytosis is a primary explored mechanism to internalize NPs into tumor cells. During the endocytosis process, properties of NPs, including size, shape, and surface functionality, play an important role in determining the final drug delivery efficacy. Many of these NP properties have been extensively explored individually. However, the multiple NP properties naturally interplay with each other in the endocytosis process to determine the internalization efficiency together. Therefore, it is significantly important to understand the interplay of different NP properties to improve the NP's final delivery efficacy. In this review, we focus on the interplay of NPs properties on the endocytosis process to summarize the relevant experimental observations and physical mechanisms. Particularly, three different aspects are discussed in detail, including the interplay between size and shape; size and elasticity; shape and elasticity. We have summarized the most recent works and highlighted that building up systematic understandings for the complex interplay between NP properties can greatly help a better design of NP platforms for drug delivery.
关键词	nanoparticle endocytosis nanoparticle properties
DOI	10.3390/cryst11070728
收录类别	SCI
语种	英语
WOS记录号	WOS:000676577300001
关键词[WOS]	RECEPTOR-LIGAND BINDING ; CELLULAR UPTAKE ; DRUG-DELIVERY ; PEGYLATED NANOPARTICLES ; SURFACE-CHEMISTRY ; SIZE ; SHAPE ; STIFFNESS ; PENETRATION ; PHARMACOKINETICS
WOS研究方向	Crystallography ; Materials Science
WOS类目	Crystallography ; Materials Science, Multidisciplinary
资助项目	NSFC Basic Science Center Program[11988102] ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102]
项目资助者	NSFC Basic Science Center Program ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
论文分区	二类
力学所作者排名	1
RpAuthor	Li, Long
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/87075
专题	非线性力学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang XH,Li L,Song F. Interplay of Nanoparticle Properties during Endocytosis[J]. CRYSTALS,2021,11,7,:13.
APA	王小环,李龙,&宋凡.(2021).Interplay of Nanoparticle Properties during Endocytosis.CRYSTALS,11(7),13.
MLA	王小环,et al."Interplay of Nanoparticle Properties during Endocytosis".CRYSTALS 11.7(2021):13.

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