| Effect of drag-reducing polymer on blood flow in microchannels | |
Li, Guanjie1; Sun, Yang1; Zheng X(郑旭)2; Choi, Hyoung Jin3; Zhang, Ke1
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| 通讯作者 | Zheng, Xu(zhengxu@lnm.imech.ac.cn) ; Zhang, Ke(zhangke@hit.edu.cn) |
| 发表期刊 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 2022 | |
| 卷号 | 209页码:7 |
| ISSN | 0927-7765 |
| 摘要 | Drag-reducing polymers (DRPs) can significantly improve blood circulation when added to blood at a nanomolar concentration, manifesting great potential for application in the biomedical field. In this work, hyaluronic acid (HA) was selected as a natural DRP, and its effects on blood microcirculation at different concentrations, flow rates, and channel geometry were studied in microchannels. The experimental results show that adding a small dose of HA can increase the velocity and shorten the thickness of the cell-free layer (CFL or cell depletion layer (CDL)) near the wall. After considering efficiency, our experiments determined 50 ppm addition of HA to be the most suitable amount for improving blood circulation. Our results demonstrate that HA has high efficiency in improving the circulation of blood flow and shed light on unveiling the mechanism of using natural DRPs to cure some cardiovascular diseases. |
| 关键词 | Hyaluronic acid Red blood cell Velocity Cell-free layer Microcirculation |
| DOI | 10.1016/j.colsurfb.2021.112212 |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000720947900004 |
| 关键词[WOS] | FREE LAYER WIDTH ; CELL ; MARGINATION ; AGGREGATION ; MICROCIRCULATION ; REDUCTION ; PERFUSION ; OXIDE |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| WOS类目 | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 资助项目 | National Natural Science Foundation of China[51603056] ; National Natural Science Foundation of China[11572335] ; Excellent Youth Foundation of Heilongjiang Province of China[YQ2019E020] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program[XDB22040403] |
| 项目资助者 | National Natural Science Foundation of China ; Excellent Youth Foundation of Heilongjiang Province of China ; CAS Key Research Program of Frontier Sciences ; CAS Strategic Priority Research Program |
| 论文分区 | 二类/Q1 |
| 力学所作者排名 | 1 |
| RpAuthor | Zheng, Xu ; Zhang, Ke |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/87997 |
| 专题 | 非线性力学国家重点实验室 |
| 作者单位 | 1.Harbin Inst Technol, MITT Key Lab Crit Mat Technol New Energy Convers, Sch Chem & Chem Engn, Harbin 150001, Peoples R China; 2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 3.Inha Univ, Dept Polymer Sci & Engn, Incheon 22212, South Korea |
| 推荐引用方式 GB/T 7714 | Li, Guanjie,Sun, Yang,Zheng X,et al. Effect of drag-reducing polymer on blood flow in microchannels[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,209:7. |
| APA | Li, Guanjie,Sun, Yang,郑旭,Choi, Hyoung Jin,&Zhang, Ke.(2022).Effect of drag-reducing polymer on blood flow in microchannels.COLLOIDS AND SURFACES B-BIOINTERFACES,209,7. |
| MLA | Li, Guanjie,et al."Effect of drag-reducing polymer on blood flow in microchannels".COLLOIDS AND SURFACES B-BIOINTERFACES 209(2022):7. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Jp2022FA567_2022_Eff（4789KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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