| Insights into intercellular receptor-ligand binding kinetics in cell communication | |
An, Chenyi1,6; Wang, Xiaohuan2; Song F(宋凡) ; Hu, Jinglei5,8; Li L(李龙)
| |
| 发表期刊 | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
 |
| 2022-06 | |
| 卷号 | 10页码:953353 |
| ISSN | 2296-4185 |
| 摘要 | Cell-cell communication is crucial for cells to sense, respond and adapt to environmental cues and stimuli. The intercellular communication process, which involves multiple length scales, is mediated by the specific binding of membrane-anchored receptors and ligands. Gaining insight into two-dimensional receptor-ligand binding kinetics is of great significance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. To this end, extensive studies have been performed to illuminate the underlying mechanisms that control intercellular receptor-ligand binding kinetics via experiment, theoretical analysis and numerical simulation. It has been well established that the cellular microenvironment where the receptor-ligand interaction occurs plays a vital role. In this review, we focus on the advances regarding the regulatory effects of three factors including 1) protein-membrane interaction, 2) biomechanical force, and 3) bioelectric microenvironment to summarize the relevant experimental observations, underlying mechanisms, as well as their biomedical significances and applications. Meanwhile, we introduce modeling methods together with experiment technologies developed for dealing with issues at different scales. We also outline future directions to advance the field and highlight that building up systematic understandings for the coupling effects of these regulatory factors can greatly help pharmaceutical development. |
| 关键词 | cell communication intercellular receptor-ligand binding kinetics protein-membrane interaction biomechanical force bioelectric microenvironment |
| 学科领域 | Biotechnology & Applied Microbiology ; Multidisciplinary Sciences |
| DOI | 10.3389/fbioe.2022.953353 |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000823655300001 |
| 项目资助者 | National Natural Science Foundation of China [11902327, 11972041, 12102389, 22161132012, 21973040] ; Youth In11ation Promotion Association CAS, China Postdoctoral Science Foundation [2020M681834] |
| 论文分区 | 二类/Q1 |
| 力学所作者排名 | 1 |
| RpAuthor | 李龙 ; Hu Jinglei |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/90166 |
| 专题 | 非线性力学国家重点实验室 |
| 作者单位 | 1.Guizhou Med Univ, Sch Biol & Engn, Guiyang, Peoples R China 2.Zhejiang Univ, Sch Med, Dept Cell Biol, Hangzhou, Peoples R China 3.Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China 4.Chinese Acad Sci, State Key Lab Nonlinear Mech, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 6.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China 7.Zhejiang Univ, Sch Med, Dept Cardiol, Affiliated Hosp 2, Hangzhou, Peoples R China 8.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China 9.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Chenyi,Wang, Xiaohuan,Song F,et al. Insights into intercellular receptor-ligand binding kinetics in cell communication[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:953353. |
| APA | An, Chenyi,Wang, Xiaohuan,宋凡,Hu, Jinglei,&李龙.(2022).Insights into intercellular receptor-ligand binding kinetics in cell communication.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10,953353. |
| MLA | An, Chenyi,et al."Insights into intercellular receptor-ligand binding kinetics in cell communication".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):953353. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Jp2022FA336_2022_Ins（1265KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论