Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids

doi:10.1063/5.0100911

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	Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids
	Hao, Yinjing 1; Lv SQ(吕守芹)2,3 ; Li W(李旺)2,3 ; Long M(龙勉)2,3 ; Cui, Yuhong 1
通讯作者	Long, Mian(mlong@imech.ac.cn) ; Cui, Yuhong(yhcui@tju.edu.cn)
发表期刊	BIOMICROFLUIDICS
	2022-09-01
卷号	16 期号:5 页码:12
摘要	In fatty liver diseases, such as liver fibrosis and liver cirrhosis, blood flow in hepatic sinusoids, an elementary building block of the liver lobule, tends to bypass through collateral vessels inside sinusoids and presents distinct sinusoidal flows compared to normal physiological flows. It remains unclear in those flow characteristics in branched sinusoids and the correlation of pathological flows with liver lesions, mainly due to the difficulty of direct hemodynamics measurements in the sinusoids. Here, we developed a dual-branched theoretical model of hepatic sinusoidal flow to elucidate the relevant flow dynamics and mass transport. Numerical simulations, based on the lattice Boltzmann method, indicated that the flow velocity distribution in hepatic sinusoids is mainly dominated by endothelium permeability and presents a non-monotonic variation with the permeability at the fusion segment of these branched sinusoids. Flow-induced shear stress on the endothelium at the side of the Disse space exhibited a biphasic pattern, yielding a low shear stress region at the junctional site. Meanwhile, a highly polarized distribution of lipoproteins concentration was also presented at the low shear stress region, indicating a localized accumulation of typical hepatic serum proteins. Thus, this work provides the basic understanding of blood flow features and mass transport regulations in branched hepatic sinusoids. Published under an exclusive license by AIP Publishing.
DOI	10.1063/5.0100911
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000876633500002
关键词[WOS]	BLOOD-FLOW ; LIPID-METABOLISM
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
WOS类目	Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
资助项目	National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation ; [11972252] ; [QYZDJ-SSW-JSC018] ; [17JCYBJC29300]
项目资助者	National Natural Science Foundation of China (NNSFC) ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation
论文分区	二类
力学所作者排名	1
RpAuthor	Long, Mian ; Cui, Yuhong
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/90673
专题	微重力重点实验室
作者单位	1.Tianjin Univ, Dept Mech, Tianjin 300072, Peoples R China; 2.Chinese Acad Sci, Natl Micrograv Lab, Beijing Key Lab Engn Construct & Mechanobiol, Ctr Biomech & Bioengn,Key Lab Micrograv,Inst Mech, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Hao, Yinjing,Lv SQ,Li W,et al. Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids[J]. BIOMICROFLUIDICS,2022,16,5,:12.
APA	Hao, Yinjing,吕守芹,李旺,龙勉,&Cui, Yuhong.(2022).Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids.BIOMICROFLUIDICS,16(5),12.
MLA	Hao, Yinjing,et al."Biphasic flow dynamics and polarized mass transportation in branched hepatic sinusoids".BIOMICROFLUIDICS 16.5(2022):12.

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