Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis | |
Zhao, ChuanRong; Li, Jingyi; Jiang, ZhiTong; Zhu, JuanJuan; Zhao, JiaNan; Yang, QianRu; Yao, Weijuan; Pang, Wei; Li N(李宁); Yu, Miaorong; Gan, Yong; Zhou, Jing | |
发表期刊 | SMALL |
2023-01 | |
卷号 | 19期号:2页码:10.1002/smll.202204694 |
ISSN | 1613-6810 |
摘要 | Disturbed blood flow induces endothelial pro-inflammatory responses that promote atherogenesis. Nanoparticle-based therapeutics aimed at treating endothelial inflammation in vasculature where disturbed flow occurs may provide a promising avenue to prevent atherosclerosis. By using a vertical-step flow apparatus and a microfluidic chip of vascular stenosis, herein, it is found that the disk-shaped versus the spherical nanoparticles exhibit preferential margination (localization and adhesion) to the regions with the pro-atherogenic disturbed flow. By employing a mouse model of carotid partial ligation, superior targeting and higher accumulation of the disk-shaped particles are also demonstrated within disturbed flow areas than that of the spherical particles. In hyperlipidemia mice, administration of disk-shaped particles loaded with hypomethylating agent decitabine (DAC) displays greater anti-inflammatory and anti-atherosclerotic effects compared with that of the spherical counterparts and exhibits reduced toxicity than "naked" DAC. The findings suggest that shaping nanoparticles to disk is an effective strategy for promoting their delivery to atheroprone endothelia. |
关键词 | atherosclerosis decitabine endothelial inflammation hemodynamics nanoparticles |
DOI | 10.1002/smll.202204694 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000888373300001 |
关键词[WOS] | IN-VIVO ; SHAPE ; NANOPARTICLES ; ADHESION ; CELLS ; ENDOTHELIUM ; DECITABINE ; PARTICLES ; MECHANISM ; DYNAMICS |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
资助项目 | National Natural Science Foundation of China ; Ministry of Science and Technology ; [32201071] ; [81974052] ; [82270419] ; [81921001] ; [82073773] ; [82025032] ; [2022YFC2704300] |
项目资助者 | National Natural Science Foundation of China ; Ministry of Science and Technology |
论文分区 | 一类 |
力学所作者排名 | 3+ |
RpAuthor | Miaorong Yu, Yong Gan, Jing Zhou |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/90814 |
专题 | 微重力重点实验室 |
通讯作者 | Yu, Miaorong; Gan, Yong; Zhou, Jing |
作者单位 | 1.{Zhao Chuan-Rong, Jiang Zhi-Tong, Zhu Juan-Juan, Zhao Jia-Nan, Yang Qian-Ru, Yao Weijuan, Pang Wei, Zhou Jing} Peking Univ Hemorheol Ctr Sch Basic Med Sci Dept Physiol & Pathophysiol Beijing 100191 Peoples R China 2.{Zhao Chuan-Rong, Jiang Zhi-Tong, Zhu Juan-Juan, Zhao Jia-Nan, Yang Qian-Ru, Zhou Jing} Minist Educ Key Lab Mol Cardiovasc Sci Beijing 100191 Peoples R China 3.{Zhao Chuan-Rong, Jiang Zhi-Tong, Zhu Juan-Juan, Zhao Jia-Nan, Yang Qian-Ru, Zhou Jing} Peking Univ Natl Hlth Commiss Key Lab Cardiovasc Mol Biol & Re Beijing Key Lab Cardiovasc Receptors Res Beijing 100191 Peoples R China 4.{Li Jingyi, Yu Miaorong, Gan Yong} Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai 201203 Peoples R China 5.{Jiang Zhi-Tong} Peking Univ Shenzhen Hosp Dept Cardiovasc Surg Shenzhen 518036 Peoples R China 6.{Li Ning} Chinese Acad Sci Key Lab Micrograv Natl Micrograv Lab Ctr Biomech & Bioengn Beijing 100190 Peoples R China 7.{Li Ning} Chinese Acad Sci Inst Mech Beijing Key Lab Engn Construct & Mechanobiol Beijing 100190 Peoples R China 8.{Li Ning} Univ Chinese Acad Sci Sch Engn Sci Beijing 100049 Peoples R China 9.{Yu Miaorong, Gan Yong} Univ Chinese Acad Sci Beijing 100049 Peoples R China |
推荐引用方式 GB/T 7714 | Zhao, ChuanRong,Li, Jingyi,Jiang, ZhiTong,et al. Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis[J]. SMALL,2023,19,2,:10.1002/smll.202204694. |
APA | Zhao, ChuanRong.,Li, Jingyi.,Jiang, ZhiTong.,Zhu, JuanJuan.,Zhao, JiaNan.,...&Zhou, Jing.(2023).Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis.SMALL,19(2),10.1002/smll.202204694. |
MLA | Zhao, ChuanRong,et al."Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis".SMALL 19.2(2023):10.1002/smll.202204694. |
条目包含的文件 | 下载所有文件 | |||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Jp2022FA064.pdf(4465KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论