| Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction |
| Li L(李龙); Ji, Jing; Song F(宋凡) ; Hu, Jinglei
|
| 通讯作者 | Ji, Jing(09714@buaa.edu.cn)
; Hu, Jinglei(hujinglei@nju.edu.cn)
|
| 发表期刊 | JOURNAL OF MOLECULAR BIOLOGY
 |
| 2023-01-15
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| 卷号 | 435期号:1页码:17 |
| ISSN | 0022-2836
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| 摘要 | Gaining insights into the intercellular receptor-ligand binding is of great importance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. In contrast to the in vitro protein interaction in solution, the anchored receptor and ligand mole-cules interact with membrane in situ, which affects the intercellular receptor-ligand binding. Here, we review theoretical, simulation and experimental works regarding the regulatory effects of protein -membrane interactions on intercellular receptor-ligand binding mainly from the following aspects: mem-brane fluctuations, membrane curvature, glycocalyx, and lipid raft. In addition, we discuss biomedical sig-nificances and possible research directions to advance the field and highlight the importance of understanding of coupling effects of these factors in pharmaceutical development.(c) 2022 Elsevier Ltd. All rights reserved. |
| 关键词 | Protein-membrane interaction
Intercellular receptor-ligand binding
Membrane fluctuations and curvature
Glycocalyx
Lipid raft
|
| DOI | 10.1016/j.jmb.2022.167787
|
| 收录类别 | SCI
|
| 语种 | 英语
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| WOS记录号 | WOS:000913850700001
|
| 关键词[WOS] | ATOMIC-FORCE MICROSCOPY
; CELL-ADHESION MOLECULES
; LIPID RAFTS
; ANCHORED RECEPTORS
; PLASMA-MEMBRANE
; CURVATURE GENERATION
; SIGNALING MOLECULES
; STRUCTURAL INSIGHTS
; ELASTIC PROPERTIES
; PHYSICAL BIOLOGY
|
| WOS研究方向 | Biochemistry & Molecular Biology
|
| WOS类目 | Biochemistry & Molecular Biology
|
| 资助项目 | National Natural Science Foundation of China[11902327]
; National Natural Science Foundation of China[11972041]
; National Natural Science Foundation of China[22161132012]
; National Natural Science Foundation of China[21973040]
; Youth Innovation Promotion Association CAS
|
| 项目资助者 | National Natural Science Foundation of China
; Youth Innovation Promotion Association CAS
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| 论文分区 | 二类/Q1
|
| 力学所作者排名 | 1
|
| RpAuthor | Ji, Jing
; Hu, Jinglei
|
| 引用统计 |
|
| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/91576
|
| 专题 | 非线性力学国家重点实验室
|
推荐引用方式
GB/T 7714 |
Li L,Ji, Jing,Song F,et al. Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction[J]. JOURNAL OF MOLECULAR BIOLOGY,2023,435,1,:17.
|
| APA |
李龙,Ji, Jing,宋凡,&Hu, Jinglei.(2023).Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction.JOURNAL OF MOLECULAR BIOLOGY,435(1),17.
|
| MLA |
李龙,et al."Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction".JOURNAL OF MOLECULAR BIOLOGY 435.1(2023):17.
|
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