Simulation and prediction of membrane fusion dynamics | |
Zheng Z(郑植); Lv SQ(吕守芹); Long M(龙勉) | |
发表期刊 | Theoretical & Applied Mechanics Letters |
2022 | |
卷号 | 12期号:1页码:100321 |
ISSN | 2095-0349 |
摘要 | Membrane fusion is an important process by which biological membranes perform their life activities. Simulations show that the membrane fusion process happens mainly through three pathways, where the Stalk-Pore hypothesis, in which two membranes come into close contact to form a stalk to a hemifusion intermediate, and then the fusion pore opens to achieve completely fusion, is widely accepted, and there exist two free energy barriers that break the current structural steady state for lipid rearrangement. Factors of lipid composition, mechanical environment, protein and ion have regulatory roles in the membrane fusion process by effecting membrane curvature structurally and the free energy barriers from energetic perspective. Meanwhile, many theoretical models, represented by the Helfrich model, have been proposed to predict the membrane fusion process. In this paper, we review the research process of membrane fusion and mainly introduce the dynamics of membrane fusion, regulation factors and typical theoretical models. |
DOI | 10.1016/j.taml.2022.100321 |
收录类别 | CSCD |
语种 | 英语 |
论文分区 | 二类 |
力学所作者排名 | 1 |
RpAuthor | Long M |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/91651 |
专题 | 微重力重点实验室 |
通讯作者 | Long M(龙勉) |
推荐引用方式 GB/T 7714 | Zheng Z,Lv SQ,Long M. Simulation and prediction of membrane fusion dynamics[J]. Theoretical & Applied Mechanics Letters,2022,12,1,:100321. |
APA | Zheng Z,Lv SQ,&Long M.(2022).Simulation and prediction of membrane fusion dynamics.Theoretical & Applied Mechanics Letters,12(1),100321. |
MLA | Zheng Z,et al."Simulation and prediction of membrane fusion dynamics".Theoretical & Applied Mechanics Letters 12.1(2022):100321. |
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