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IMECH-IR
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The significance of molecular mechanics property to protein evolution 期刊论文
INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS, 2013, 卷号: 8, 期号: 1, 页码: 83-91
作者:  Zhang LM;  Liu X(刘鑫);  Liu, X (reprint author), Chinese Acad Sci, State Key Lab Nonlinear Mech, Inst Mech, 15 Beisihuanxi Rd, Beijing 100190, Peoples R China.
Adobe PDF(102Kb)  |  收藏  |  浏览/下载：473/179  |  提交时间：2013/09/09
Hydrophobic Interaction  Protein Evolution  Mechanics Property  
Appendant structure plays an important role in amyloidogenic cystatin dimerization prior to domain swapping 期刊论文
Journal of Biomolecular Structure & Dynamics, 2012, 卷号: 30, 期号: 1, 页码: 102-112
作者:  Yu YY;  Liu X(刘鑫);  He JW;  Zhang MY;  Li H;  Wei DQ;  Song YT
Adobe PDF(2363Kb)  |  收藏  |  浏览/下载：816/308  |  提交时间：2012/12/04
Chicken Cystatin  Conformational Disease  Cerebral-hemorrhage  Crystal-structure  Swiss-model  c Variant  Wild-type  Protein  Mutant  Environment  Molecular Dynamic Simulation  Domain Swapping  Appendant Structure  Amyloidosis  Hydrophobic Core  
Simulated pathogenic conformational switch regions matched well with the biochemical findings 期刊论文
Journal of Biomedical Informatics., 2010, 卷号: 43, 期号: 3, 页码: 365-375
作者:  Liu X(刘鑫);  Zhao YP(赵亚溥)
Adobe PDF(2010Kb)  |  收藏  |  浏览/下载：790/237  |  提交时间：2010/05/12
Switch Region for Pathogenic Structural Change in Conformational Disease and Its Prediction 期刊论文
PLoS One, 2010, 卷号: 5, 期号: 1, 页码: e8441
作者:  Liu X(刘鑫);  Zhao YP(赵亚溥);  Zhao YP(赵亚溥)
浏览  |  Adobe PDF(670Kb)  |  收藏  |  浏览/下载：908/203  |  提交时间：2010/05/12
Generating artificial homologous proteins according to the representative family character in molecular mechanics properties - an attempt in validating an underlying rule of protein evolution 期刊论文
FEBS Letters, 2010, 卷号: 584, 期号: 5, 页码: 1059-1065
作者:  Liu X(刘鑫);  Zhao YP(赵亚溥);  Zhao YP(赵亚溥)
浏览  |  Adobe PDF(895Kb)  |  收藏  |  浏览/下载：743/208  |  提交时间：2010/05/12
Donut-Shaped Fingerprint In Homologous Polypeptide Relationships-A Topological Feature Related To Pathogenic Structural Changes In Conformational Disease 期刊论文
Journal of Theoretical Biology, 2009, 卷号: 258, 期号: 2, 页码: 294-301
作者:  Liu X(刘鑫);  Zhao YP(赵亚溥);  Zhao YP
Adobe PDF(513Kb)  |  收藏  |  浏览/下载：727/165  |  提交时间：2009/08/03
Homologous Relationship  Polypeptide  Prion Protein  Conformational Disease  Predicting Signal Peptides  State Enzyme-kinetics  Protein-structure  Graphic Rules  Codon Usage  Rate Laws  Evolution  Steady  Model  Prion  
A scheme for multiple sequences alignment optimization-an improvement based on family representative mechanics features 期刊论文
Journal of Theoretical Biology, 2009, 卷号: 261, 期号: 4, 页码: 593-597
作者:  Liu X(刘鑫);  Zhao YP(赵亚溥)
浏览  |  Adobe PDF(493Kb)  |  收藏  |  浏览/下载：644/158  |  提交时间：2009/12/28
Scoring Scheme  Hydrophobic Interaction  Multiple Sequence Alignment  Homologous Proteins  
A combined statistical model for multiple motifs search 期刊论文
Chinese Physics B, 2008, 卷号: 17, 期号: 12, 页码: 4396
作者:  Gao LF(高丽锋);  Liu X(刘鑫);  Guan S(官山);  Guan S
浏览  |  Adobe PDF(1074Kb)  |  收藏  |  浏览/下载：666/170  |  提交时间：2010/05/12
Transcription Factor Binding Sites  Motif  Position Weight Matrix