| Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip | |
Wang CL; Li JQ ; Li HW; Jin G(靳刚); Wang ZH(王战会); Meng YH(孟永宏); Xiu RJ
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| Source Publication | Artificial Cells Blood Substitutes and Biotechnology
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| 2009 | |
| Volume | 37Issue:4Pages:183-186 |
| ISSN | 1073-1199 |
| Abstract | The Tie-2 receptor has been shown to play a role in angiogenesis in atherosclerosis. The conventional method assaying the level of soluble Tie-2 (sTie-2) was ELISA. However, this method has some disadvantages. The aims of this research are to establish a more simple detection method, the optical protein-chip based on imaging ellipsomtry (OPC-IE) applying to Tie-2 assay. The sTie-2 biosensor surface on silicon wafer was prepared first, and then serum levels of sTie-2 in 38 patients with AMI were measured on admission (day 1), day 2, day 3 and day 7 after onset of chest pain and 41 healthy controls by ELISA and OPC-IE in parallel. Median level of sTie-2 increased significantly in the AMI patients when compared with the controls. Statistics showed there was a significant correlation in sTie-2 results between the two methods (r=0.923, P0.01). The result of this study showed that the level of sTie-2 increased in AMI, and OPC-IE assay was a fast, reliable, and convenient technique to measure sTie-2 in serum. |
| Keyword | Soluble Tie-2 Acute Myocardial Infarction Elisa Optical Protein-chip Imaging Ellipsometry Imaging Ellipsometry Tyrosine Kinase Tek |
| DOI | 10.1080/10731190903043416 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000267835500007 |
| WOS Keyword | IMAGING ELLIPSOMETRY ; TYROSINE KINASE ; TEK |
| WOS Research Area | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| WOS Subject | Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/26690 |
| Collection | 微重力重点实验室 |
| Corresponding Author | Wang CL |
| Recommended Citation GB/T 7714 | Wang CL,Li JQ,Li HW,et al. Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip[J]. Artificial Cells Blood Substitutes and Biotechnology,2009,37,4,:183-186. |
| APA | Wang CL.,Li JQ.,Li HW.,Jin G.,Wang ZH.,...&Xiu RJ.(2009).Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip.Artificial Cells Blood Substitutes and Biotechnology,37(4),183-186. |
| MLA | Wang CL,et al."Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip".Artificial Cells Blood Substitutes and Biotechnology 37.4(2009):183-186. |
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| GZ11001719.pdf（89KB） | 开放获取 | -- | View Download | |||
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