Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells | |
Li H(李红); Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉); Long M | |
Source Publication | Science China-Life Sciences |
2010 | |
Volume | 53Issue:9Pages:1085-1091 |
ISSN | 1674-7305 |
Abstract | Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity. |
Keyword | Substrate Orientation Osteoblasts Cell Shape Cell Cycle Cytoskeleton Random Positioning Machine Microgravity Osteoblasts Space Spaceflight Adhesion Gravity Nuclei Flight |
DOI | 10.1007/s11427-010-4057-6 |
URL | 查看原文 |
Indexed By | SCI |
Language | 英语 |
WOS ID | WOS:000282479500005 |
WOS Keyword | RANDOM POSITIONING MACHINE ; MICROGRAVITY ; OSTEOBLASTS ; SPACE ; SPACEFLIGHT ; ADHESION ; GRAVITY ; NUCLEI ; FLIGHT |
WOS Research Area | Life Sciences & Biomedicine - Other Topics |
WOS Subject | Biology |
Funding Organization | Chinese Academy of Sciences [KJCX2-YW-L08] ; National Natural Science Foundation of China [30730032, 30730093] ; National Key Basic Research Foundation of China [2006CB910303] ; National High Technology Research and Development Program of China [2007AA02Z306] |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://dspace.imech.ac.cn/handle/311007/43627 |
Collection | 微重力重点实验室 |
Corresponding Author | Long M |
Recommended Citation GB/T 7714 | Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010,53,9,:1085-1091. |
APA | Li H.,陈娟.,章燕.,孙树津.,陶祖莱.,...&Long M.(2010).Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.Science China-Life Sciences,53(9),1085-1091. |
MLA | Li H,et al."Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells".Science China-Life Sciences 53.9(2010):1085-1091. |
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