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Title:
Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells
Author: Li H(李红); Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉)
Source: Science China-Life Sciences
Issued Date: 2010
Volume: 53, Issue:9, Pages:1085-1091
Abstract: Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.
Keyword: Substrate Orientation ; Osteoblasts ; Cell Shape ; Cell Cycle ; Cytoskeleton ; Random Positioning Machine ; Microgravity ; Osteoblasts ; Space ; Spaceflight ; Adhesion ; Gravity ; Nuclei ; Flight
Language: 英语
Indexed Type: SCI
Corresponding Author: Long M
Correspondent Email: mlong@imech.ac.cn
DOI: 10.1007/s11427-010-4057-6
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Biology
WOS Subject Extended: Life Sciences & Biomedicine - Other Topics
WOS Keyword Plus: RANDOM POSITIONING MACHINE ; MICROGRAVITY ; OSTEOBLASTS ; SPACE ; SPACEFLIGHT ; ADHESION ; GRAVITY ; NUCLEI ; FLIGHT
WOS ID: WOS:000282479500005
ISSN: 1674-7305
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/43627
Appears in Collections:国家微重力实验室_期刊论文

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Recommended Citation:
Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010-01-01,53(9):1085-1091.
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