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Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells
Li H(李红); Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉); Long M
2010
发表期刊Science China-Life Sciences
卷号53期号:9页码:1085-1091
ISSN1674-7305
摘要Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity.
关键词Substrate Orientation Osteoblasts Cell Shape Cell Cycle Cytoskeleton Random Positioning Machine Microgravity Osteoblasts Space Spaceflight Adhesion Gravity Nuclei Flight
DOI10.1007/s11427-010-4057-6
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收录类别SCI
语种英语
WOS记录号WOS:000282479500005
关键词[WOS]RANDOM POSITIONING MACHINE ; MICROGRAVITY ; OSTEOBLASTS ; SPACE ; SPACEFLIGHT ; ADHESION ; GRAVITY ; NUCLEI ; FLIGHT
WOS研究方向Life Sciences & Biomedicine - Other Topics
WOS类目Biology
项目资助者Chinese Academy of Sciences [KJCX2-YW-L08] ; National Natural Science Foundation of China [30730032, 30730093] ; National Key Basic Research Foundation of China [2006CB910303] ; National High Technology Research and Development Program of China [2007AA02Z306]
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/43627
专题国家微重力实验室
通讯作者Long M
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GB/T 7714
Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010,53(9):1085-1091.
APA Li H.,陈娟.,章燕.,孙树津.,陶祖莱.,...&Long M.(2010).Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.Science China-Life Sciences,53(9),1085-1091.
MLA Li H,et al."Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells".Science China-Life Sciences 53.9(2010):1085-1091.
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