| Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells |
| Li H(李红) ; Chen J(陈娟); Zhang Y(章燕); Sun SJ(孙树津); Tao ZL(陶祖莱); Long M(龙勉); Long M
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| 发表期刊 | Science China-Life Sciences
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| 2010
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| 卷号 | 53期号:9页码:1085-1091 |
| ISSN | 1674-7305
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| 摘要 | Absence of gravity or microgravity influences the cellular functions of bone forming osteoblasts. The underlying mechanism, however, of cellular sensing and responding to the gravity vector is poorly understood. This work quantified the impact of vector-directional gravity on the biological responses of Ros 17/2.8 cells grown on upward-, downward- or edge-on-oriented substrates. Cell morphology and nuclear translocation, cell proliferation and the cell cycle, and cytoskeletal reorganization were found to vary significantly in the three orientations. All of the responses were duration-dependent. These results provide a new insight into understanding how osteoblasts respond to static vector-directional gravity. |
| 关键词 | Substrate Orientation
Osteoblasts
Cell Shape
Cell Cycle
Cytoskeleton
Random Positioning Machine
Microgravity
Osteoblasts
Space
Spaceflight
Adhesion
Gravity
Nuclei
Flight
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| DOI | 10.1007/s11427-010-4057-6
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| URL | 查看原文
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000282479500005
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| 关键词[WOS] | RANDOM POSITIONING MACHINE
; MICROGRAVITY
; OSTEOBLASTS
; SPACE
; SPACEFLIGHT
; ADHESION
; GRAVITY
; NUCLEI
; FLIGHT
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| WOS研究方向 | Life Sciences & Biomedicine - Other Topics
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| WOS类目 | Biology
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| 项目资助者 | Chinese Academy of Sciences [KJCX2-YW-L08]
; National Natural Science Foundation of China [30730032, 30730093]
; National Key Basic Research Foundation of China [2006CB910303]
; National High Technology Research and Development Program of China [2007AA02Z306]
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/43627
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| 专题 | 微重力重点实验室
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| 通讯作者 | Long M |
推荐引用方式
GB/T 7714 |
Li H,Chen J,Zhang Y,et al. Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells[J]. Science China-Life Sciences,2010,53,9,:1085-1091.
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| APA |
Li H.,陈娟.,章燕.,孙树津.,陶祖莱.,...&Long M.(2010).Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells.Science China-Life Sciences,53(9),1085-1091.
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| MLA |
Li H,et al."Effects of oriented substrates on cell morphology, the cell cycle, and the cytoskeleton in Ros 17/2.8 cells".Science China-Life Sciences 53.9(2010):1085-1091.
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