Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation

doi:10.1038/NNANO.2011.151

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	Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation
	Shi XH(施兴华); von dem Bussche A; Hurt RH; Kane AB; Gao HJ(高华健); Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
发表期刊	Nature Nanotechnology
	2011
卷号	6 期号:11 页码:714-719
ISSN	1748-3387
摘要	Materials with high aspect ratio, such as carbon nanotubes and asbestos fibres, have been shown to cause length-dependent toxicity in certain cells because these long materials prevent complete ingestion and this frustrates the cell(1-3). Biophysical models have been proposed to explain how spheres and elliptical nanostructures enter cells(4-8), but one-dimensional nanomaterials have not been examined. Here, we show experimentally and theoretically that cylindrical one-dimensional nanomaterials such as carbon nanotubes enter cells through the tip first. For nanotubes with end caps or carbon shells at their tips, uptake involves tip recognition through receptor binding, rotation that is driven by asymmetric elastic strain at the tube-bilayer interface, and near-vertical entry. The precise angle of entry is governed by the relative timescales for tube rotation and receptor diffusion. Nanotubes without caps or shells on their tips show a different mode of membrane interaction, posing an interesting question as to whether modifying the tips of tubes may help avoid frustrated uptake by cells.
关键词	Walled Carbon Nanotubes Receptor-mediated Endocytosis Asbestos Phagocytosis Nanoparticles Toxicity Inflammation Macrophages Crocidolite Responses
学科领域	Science & Technology - Other Topics ; Materials Science
DOI	10.1038/NNANO.2011.151
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000296737300009
关键词[WOS]	WALLED CARBON NANOTUBES ; RECEPTOR-MEDIATED ENDOCYTOSIS ; ASBESTOS ; PHAGOCYTOSIS ; NANOPARTICLES ; TOXICITY ; INFLAMMATION ; MACROPHAGES ; CROCIDOLITE ; RESPONSES
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者	This work was supported by the National Science Foundation (NSF; grant CMMI-1028530), the US Department of Commerce, National Institute of Standards and Technology as part of the Rhode Island Consortium for Nanoscience and Nanotechnology, the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42 ES013660, and an R01 grant (ES016178) from the NIEHS. The simulations reported were performed on NSF TeraGrid resources provided by National Institute for Computational Sciences (NICS; under MCB090194) and resources from the Supercomputing Center of Chinese Academy of Sciences (SCCAS) and Shanghai Supercomputer Center (SSC). The authors thank P. Weston in the Molecular Pathology Core at Brown University for her assistance with electron microscopic sample preparation and imaging and F. Guo for measurement of MWCNT zeta potentials.
课题组名称	LNM微结构计算力学（筹）
论文分区	一类
引用统计	被引频次：379[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/44897
专题	非线性力学国家重点实验室
通讯作者	Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Shi XH,von dem Bussche A,Hurt RH,et al. Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation[J]. Nature Nanotechnology,2011,6,11,:714-719.
APA	施兴华,von dem Bussche A,Hurt RH,Kane AB,高华健,&Shi, XH .(2011).Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation.Nature Nanotechnology,6(11),714-719.
MLA	施兴华,et al."Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation".Nature Nanotechnology 6.11(2011):714-719.

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