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Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin
Feuerecker M; Feuerecker B; Matzel S; Long M(龙勉); Strewe C; Kaufmann I; Hoerl M; Schelling G; Rehm M; Chouker A; Chouker, A (reprint author), Univ Munich, Dept Anaesthesiol, Marchioninistr 15, D-81377 Munich, Germany.
Source PublicationJOURNAL OF APPLIED PHYSIOLOGY
2013-07-01
Volume115Issue:2Pages:235-242
ISSN8750-7587
AbstractHead-down-tilt bed rest (HDTBR) is a popular model, simulating alterations of gravitation during space missions. The aim of this study was to obtain a better insight into the complexly orchestrated regulations of HDTBR-induced immunological responses, hypothesizing that artificial gravity can mitigate these HDTBR-related physiological effects. This crossover-designed 5 days of HDTBR study included three protocols with no, or daily 30 min of centrifugation or 6 X 5 min of centrifugation. Twelve healthy, male participants donated blood pre-HDTBR, post-HDTBR, and twice during HDTBR. Cellular immune changes were assessed either by enumerative and immune cell phenotyping assays or by functional testing of responses to either recall antigens or receptor-dependent activation by chemotactic agents N-formyl-methionyl-leucyl-phenylalanine (fMLP) and with TNF-alpha. The expression of the adhesion molecule L-selectin (CD62L) on the surface of granulocytes and its shedding into plasma samples were measured. In parallel, other humoral factor, such as interleukin-6 and interleukin-8, parameters of endothelial damage (glycocalyx) were determined. Hematocrit and hemoglobin were significantly increased during HDTBR. Although immune functional tests did not indicate a change in the immune performance, the expression of CD62L on resting granulocytes was significantly shed by 50% during HDTBR. Although the latter is normally associated to an activation of inflammatory innate immune responses and during interaction of granulocytes with the endothelium, CD62L shedding was, however, not related either to a systemic inflammatory alteration or to shedding of the endothelial glycocalyx during bed rest. This suggests a noninflammatory or "mechanical" shedding related to fluid shifts during head-down intervention and not to an acute inflammatory process.
KeywordCd62l Shedding Immunological Changes Short-term Bed Rest
Subject Area交叉与边缘领域的力学
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Indexed BySCI
Language英语
WOS IDWOS:000321819000012
Funding OrganizationEuropean Space Agency; German National Space Program [50WB0719/WB0919]
DepartmentNML分子-细胞生物力学与空间生命科学
Classification二类/Q1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/47359
Collection国家微重力实验室
Corresponding AuthorChouker, A (reprint author), Univ Munich, Dept Anaesthesiol, Marchioninistr 15, D-81377 Munich, Germany.
Recommended Citation
GB/T 7714
Feuerecker M,Feuerecker B,Matzel S,et al. Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin[J]. JOURNAL OF APPLIED PHYSIOLOGY,2013,115(2):235-242.
APA Feuerecker M.,Feuerecker B.,Matzel S.,Long M.,Strewe C.,...&Chouker, A .(2013).Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin.JOURNAL OF APPLIED PHYSIOLOGY,115(2),235-242.
MLA Feuerecker M,et al."Five days of head-down-tilt bed rest induces noninflammatory shedding of L-selectin".JOURNAL OF APPLIED PHYSIOLOGY 115.2(2013):235-242.
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