IMECH-IR  > 力学所知识产出(1956-2008)
胶原Ⅰ对鼠骨肉瘤ROS17/2.8细胞增殖和分化影响的研究
应佩青; 李涛; 靳刚; 陶祖莱
Source Publication21世纪医学工程学术研讨会论文摘要汇编
2001
Pages49-49
Conference Name21世纪医学工程学术研讨会
Conference Date2001-10-1
Conference Place中国北京
Abstract细胞外基质(extracellular matrix,ECM)影响细胞的显型表达和分化,如上皮细胞和肝细胞。胶原作为骨细胞的主要胞外基质成份,常被用于体外细胞培养,以利于细胞的粘附和生长。已有的研究认为胶原Ⅰ影响骨细胞显型的表达,并对成骨细胞显型的发育表达和矿化基质的形成起关键作用。如胎鼠颅骨成骨细胞在胶原Ⅰ基质上的培养可加速成骨细胞发育进程,细胞增殖减慢,绕过基质合成期,细胞分化提前。而人骨肉瘤MG-63细胞在胶原基质和无胶原基质上的生长并无明显区别。
Keyword细胞增殖和分化 胶原ⅰ 鼠骨 影响 体外细胞培养 成骨细胞 人骨肉瘤 矿化基质 基质合成 胶原基质
Department力学所
Language中文
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/48140
Collection力学所知识产出(1956-2008)
Recommended Citation
GB/T 7714
应佩青,李涛,靳刚,等. 胶原Ⅰ对鼠骨肉瘤ROS17/2.8细胞增殖和分化影响的研究[C],2001:49-49.
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