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Title: Kinetic behaviour of the cells touching substrate: the interfacial stiffness guides cell spreading
Author: Li JJ; Han D; Zhao YP(赵亚溥)
Source: Scientific Reports
Issued Date: 2014-01-28
Volume: 4, Pages:3910
Abstract: To describe detailed behaviour of cell spreading under the influence of substrate stiffness, A549 cells cultured on the surfaces of polydimethylsiloxane (PDMS) and polyacrylamide (PAAm) with bulk rigidities ranging from 0.1 kPa to 40 kPa were in situ observed. The spreading behaviour of cells on PAAm presented a positive correlation between spreading speed and substrate stiffness. After computing the deformations of PAAm gels and collagen, the bulk stiffness of PAAm, rather than matrix tethering, determined the cell behaviour. On the other hand, spreading behaviour of the cells was unaffected by varying the bulk stiffness of PDMS. Based on simulation analyses, the elasticity of silica-like layer induced by UV radiation on PDMS surface dominated cell-substrate interaction, rather than the bulk stiffness of the material, indicating that it is the interfacial stiffness that mainly guided the cell spreading. And then the kinetics of cell spreading was for the first time modeled based on absolute rate theory.
Language: 英语
Indexed Type: SCI
Corresponding Author: Zhao, YP (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
Correspondent Email: dhan@nanoctr.cn; yzhao@imech.ac.cn
Related URLs: 查看原文
DOC Type: Article
WOS ID: WOS:000331152700004
ISSN: 2045-2322
Rank: [Li, Jianjun; Zhao, Ya-Pu] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Han, Dong] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
Subject: Science & Technology - Other Topics
Department: LNM纳/微系统力学与物理力学
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/48779
Appears in Collections:非线性力学国家重点实验室_期刊论文

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Recommended Citation:
Li, JJ; Han, D; 赵亚溥.Kinetic behaviour of the cells touching substrate: the interfacial stiffness guides cell spreading,SCIENTIFIC REPORTS,2014,4():3910
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