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A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles
Wang JD; Chen WW; Sun JS; Liu C(刘超); Yin QF; Zhang L; Xianyu YL; Shi XH(施兴华); Hu GQ(胡国庆); Jiang XY; Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Source PublicationLAB ON A CHIP
2014
Volume14Issue:10Pages:1673-1677
ISSN1473-0197
AbstractThis report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.
Subject AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
DOI10.1039/c4lc00080c
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000334866500004
Funding OrganizationX. J. and J. S. acknowledge financial support from MOST (2011CB933201, 2012AA030308, 2012AA022703 and 2013AA032204), NSFC (51105086, 91213305, 21025520, and 51073045), and the Chinese Academy of Sciences and Beijing Municipal Science & Technology Commission (Z131100002713024).
DepartmentLNM微结构计算力学(筹)
Classification一类
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/48835
Collection非线性力学国家重点实验室
Corresponding AuthorSun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
Recommended Citation
GB/T 7714
Wang JD,Chen WW,Sun JS,et al. A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles[J]. LAB ON A CHIP,2014,14(10):1673-1677.
APA Wang JD.,Chen WW.,Sun JS.,Liu C.,Yin QF.,...&Sun, JS .(2014).A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles.LAB ON A CHIP,14(10),1673-1677.
MLA Wang JD,et al."A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles".LAB ON A CHIP 14.10(2014):1673-1677.
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