A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles

doi:10.1039/c4lc00080c

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	A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles
	Wang JD; Chen WW; Sun JS; Liu C(刘超); Yin QF; Zhang L; Xianyu YL; Shi XH(施兴华); Hu GQ(胡国庆); Jiang XY; Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
发表期刊	LAB ON A CHIP
	2014
卷号	14 期号:10 页码:1673-1677
ISSN	1473-0197
摘要	This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications.
学科领域	Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
DOI	10.1039/c4lc00080c
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000334866500004
项目资助者	X. J. and J. S. acknowledge financial support from MOST (2011CB933201, 2012AA030308, 2012AA022703 and 2013AA032204), NSFC (51105086, 91213305, 21025520, and 51073045), and the Chinese Academy of Sciences and Beijing Municipal Science & Technology Commission (Z131100002713024).
课题组名称	LNM微结构计算力学（筹）
论文分区	一类
引用统计	被引频次：66[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/48835
专题	非线性力学国家重点实验室
通讯作者	Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Wang JD,Chen WW,Sun JS,et al. A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles[J]. LAB ON A CHIP,2014,14,10,:1673-1677.
APA	Wang JD.,Chen WW.,Sun JS.,Liu C.,Yin QF.,...&Sun, JS .(2014).A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles.LAB ON A CHIP,14(10),1673-1677.
MLA	Wang JD,et al."A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles".LAB ON A CHIP 14.10(2014):1673-1677.

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