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Title:
Mechanokinetics of receptor-ligand interactions in cell adhesion
Author: Li N(李宁); Lv SQ(吕守琴); Zhang Y(章燕); Long M(龙勉)
Source: Acta Mechanica Sinica
Issued Date: 2015-04
Volume: 31, Issue:2, Pages:248-258
Abstract: Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in the immune system, 2D kinetics and its regulations have been less understood, since no theoretical framework or experimental assays were established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands. Here, we provide an overview of current progress in 2D binding and regulations, mainly from our group. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations are discussed. A neutrophil undergoes capture and rolling (or tethering) on the endothelium through selectin-PSGL-1 bonds, followed by slow rolling and firm adhesion through the -integrins LFA-1 and Mac-1 as well as intraluminal crawling and transmigration through the endothelium to the inflamed tissue.
Keyword: Receptor-ligand interactions ; Selectins ; beta(2) integrins ; 2D binding kinetics
Language: 英语
Indexed Type: SCI ; EI ; CSCD
Corresponding Author: Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Correspondent Email: mlong@imech.ac.cn
DOI: 10.1007/s10409-015-0407-8
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Engineering, Mechanical ; Mechanics
WOS Subject Extended: Engineering ; Mechanics
WOS ID: WOS:000355315900011
ISSN: 0567-7718
Funder: Natural Science Foundation of China [10042001, 10072071, 10128205, 30225027, 10332060, 30730032, 11072251, 31110103918] ; National Key Basic Research Foundation of China [2006CB910303, 2011CB710904] ; National High Technology Research and Development Program of China [2007AA02Z306, 2011AA020109] ; Chinese Academy of Sciences [KJCX2-L02, KJCX2-SW-L06, 2005-1-16, KJCX2-YW-L08, Y2010030, XDA01030102, XDA04073 801] ; NIH Fogarty International Research Collaboration Award [TW 05774-01]
Rank: [Li, Ning; Lu, Shouqin; Zhang, Yan; Long, Mian] Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; [Li, Ning; Lu, Shouqin; Zhang, Yan; Long, Mian] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
Department: NML分子-细胞生物力学与空间生命科学
Classification: 二类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/54973
Appears in Collections:国家微重力实验室_期刊论文

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Recommended Citation:
Li N,Lv SQ,Zhang Y,et al. Mechanokinetics of receptor-ligand interactions in cell adhesion[J]. Acta Mechanica Sinica,2015-04-01,31(2):248-258.
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