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Mechanokinetics of receptor-ligand interactions in cell adhesion
Li N(李宁); Lv SQ(吕守芹); Zhang Y(章燕); Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
2015-04
发表期刊Acta Mechanica Sinica
卷号31期号:2页码:248-258
ISSN0567-7718
摘要

Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in the immune system, 2D kinetics and its regulations have been less understood, since no theoretical framework or experimental assays were established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands. Here, we provide an overview of current progress in 2D binding and regulations, mainly from our group. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations are discussed. A neutrophil undergoes capture and rolling (or tethering) on the endothelium through selectin-PSGL-1 bonds, followed by slow rolling and firm adhesion through the -integrins LFA-1 and Mac-1 as well as intraluminal crawling and transmigration through the endothelium to the inflamed tissue.

关键词Receptor-ligand Interactions Selectins Beta(2) Integrins 2d Binding Kinetics
DOI10.1007/s10409-015-0407-8
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收录类别SCI ; EI ; CSCD
语种英语
WOS记录号WOS:000355315900011
WOS研究方向Engineering ; Mechanics
WOS类目Engineering, Mechanical ; Mechanics
项目资助者Natural Science Foundation of China [10042001, 10072071, 10128205, 30225027, 10332060, 30730032, 11072251, 31110103918] ; National Key Basic Research Foundation of China [2006CB910303, 2011CB710904] ; National High Technology Research and Development Program of China [2007AA02Z306, 2011AA020109] ; Chinese Academy of Sciences [KJCX2-L02, KJCX2-SW-L06, 2005-1-16, KJCX2-YW-L08, Y2010030, XDA01030102, XDA04073 801] ; NIH Fogarty International Research Collaboration Award [TW 05774-01]
课题组名称NML分子-细胞生物力学与空间生命科学
论文分区二类
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/54973
专题国家微重力实验室
通讯作者Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
推荐引用方式
GB/T 7714
Li N,Lv SQ,Zhang Y,et al. Mechanokinetics of receptor-ligand interactions in cell adhesion[J]. Acta Mechanica Sinica,2015,31(2):248-258.
APA Li N,Lv SQ,Zhang Y,Long M,&Long, M .(2015).Mechanokinetics of receptor-ligand interactions in cell adhesion.Acta Mechanica Sinica,31(2),248-258.
MLA Li N,et al."Mechanokinetics of receptor-ligand interactions in cell adhesion".Acta Mechanica Sinica 31.2(2015):248-258.
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