| Nanotechnology for treating osteoporotic vertebral fractures | |
| Gao CX; Wei DL; Yang HL; Chen T; Yang L; Yang, L (reprint author), Robot Microsyst Ctr, Dept Orthopaed Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China. | |
| 发表期刊 | INTERNATIONAL JOURNAL OF NANOMEDICINE
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| 2015 | |
| 卷号 | 10页码:5139-5157 |
| ISSN | 1178-2013 |
| 摘要 | Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided. |
| 关键词 | Nanomaterials Osteoporosis Vertebral Fracture Kyphoplasty Bone Cement Pedicle Screw Radiopacifier |
| 学科领域 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| DOI | 10.2147/IJN.S85037 |
| URL | 查看原文 |
| 收录类别 | SCI ; EI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359447500001 |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| WOS类目 | Nanoscience & Nanotechnology ; Pharmacology & Pharmacy |
| 项目资助者 | Jiangsu Provincial Special Program of Medical Science [BL2012004] ; Priority Academic Program Development of Jiangsu High Education Institutions ; National Basic Research Program of China (973 Program) [2014CB748600] ; Jiangsu R&D Innovation Program [BY2014059-07] ; National Natural Science Foundation of China [51472279] ; Jiangsu Six Peak of Talents Program [2013-WSW-056] ; Chinese Ministry of Education Star-up Fund for Oversea Scholars ; Open Fund of State Key Laboratory of Nonlinear Mechanics |
| 论文分区 | 一类 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/55318 |
| 专题 | 非线性力学国家重点实验室 |
| 通讯作者 | Yang, L (reprint author), Robot Microsyst Ctr, Dept Orthopaed Surg, 708 Renmin Rd, Suzhou 215006, Jiangsu, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Gao CX,Wei DL,Yang HL,et al. Nanotechnology for treating osteoporotic vertebral fractures[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:5139-5157. |
| APA | Gao CX,Wei DL,Yang HL,Chen T,Yang L,&Yang, L .(2015).Nanotechnology for treating osteoporotic vertebral fractures.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,5139-5157. |
| MLA | Gao CX,et al."Nanotechnology for treating osteoporotic vertebral fractures".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):5139-5157. |
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| IMCAS-J2015-123.pdf（4844KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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