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Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension
He XC; Lin M; Sha BY; Feng SS; Shi XH(施兴华); Qu ZG; Xu F; Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
Source PublicationSCIENTIFIC REPORTS
2015-08-03
Volume5Pages:12808
ISSN2045-2322
AbstractUnderstanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery.
Subject AreaScience & Technology - Other Topics
DOI10.1038/srep12808
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000358853400001
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation of China [51322604, 51176149, 11372243, 81301040, 11272327, 11422215] ; Major International Joint Research Program of China [11120101002] ; International Science & Technology Cooperation Program of China [2013DFG02930]
DepartmentLNM微结构计算力学(筹)
Classification一类
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/55326
Collection非线性力学国家重点实验室
Corresponding AuthorQu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
Recommended Citation
GB/T 7714
He XC,Lin M,Sha BY,et al. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension[J]. SCIENTIFIC REPORTS,2015,5:12808.
APA He XC.,Lin M.,Sha BY.,Feng SS.,Shi XH.,...&Qu, ZG .(2015).Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension.SCIENTIFIC REPORTS,5,12808.
MLA He XC,et al."Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension".SCIENTIFIC REPORTS 5(2015):12808.
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