中国科学院力学研究所机构知识库
Advanced  
IMECH-IR  > 非线性力学国家重点实验室  > 期刊论文
Title:
Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension
Author: He XC; Lin M; Sha BY; Feng SS; Shi XH(施兴华); Qu ZG; Xu F
Source: SCIENTIFIC REPORTS
Issued Date: 2015-08-03
Volume: 5, Pages:12808
Abstract: Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery.
Language: 英语
Indexed Type: SCI
Corresponding Author: Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
Correspondent Email: zgqu@mail.xjtu.edu.cn ; fengxu@mail.xjtu.edu.cn
DOI: 10.1038/srep12808
Related URLs: 查看原文
DOC Type: Article
WOS Subject: Multidisciplinary Sciences
WOS Subject Extended: Science & Technology - Other Topics
WOS ID: WOS:000358853400001
ISSN: 2045-2322
Funder: National Natural Science Foundation of China [51322604, 51176149, 11372243, 81301040, 11272327, 11422215] ; Major International Joint Research Program of China [11120101002] ; International Science & Technology Cooperation Program of China [2013DFG02930]
Rank: [He, XiaoCong; Qu, ZhiGuo] Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China; [He, XiaoCong; Lin, Min; Sha, BaoYong; Feng, ShangSheng; Qu, ZhiGuo; Xu, Feng] Xi An Jiao Tong Univ, BEBC, Xian 710049, Peoples R China; [Lin, Min; Xu, Feng] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China; [Sha, BaoYong] Xian Med Univ, Inst Basic Med Sci, Xian 710021, Peoples R China; [Shi, XingHua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100864, Peoples R China
Subject: Science & Technology - Other Topics
Department: LNM微结构计算力学(筹)
Classification: 一类
Citation statistics:
Content Type: 期刊论文
URI: http://dspace.imech.ac.cn/handle/311007/55326
Appears in Collections:非线性力学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
IMCAS-J2015-133.pdf(2290KB)期刊论文出版稿开放获取View Download

Recommended Citation:
He XC,Lin M,Sha BY,et al. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension[J]. SCIENTIFIC REPORTS,2015-08-03,5:12808.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[He XC]'s Articles
[Lin M]'s Articles
[Sha BY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[He XC]‘s Articles
[Lin M]‘s Articles
[Sha BY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: IMCAS-J2015-133.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院力学研究所 - Feedback
Powered by CSpace