| Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension |
| He XC; Lin M ; Sha BY; Feng SS; Shi XH(施兴华); Qu ZG; Xu F; Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
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| 发表期刊 | SCIENTIFIC REPORTS
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| 2015-08-03
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| 卷号 | 5页码:12808 |
| ISSN | 2045-2322
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| 摘要 | Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery. |
| 学科领域 | Science & Technology - Other Topics
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| DOI | 10.1038/srep12808
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| URL | 查看原文
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS记录号 | WOS:000358853400001
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| 项目资助者 | National Natural Science Foundation of China [51322604, 51176149, 11372243, 81301040, 11272327, 11422215]
; Major International Joint Research Program of China [11120101002]
; International Science & Technology Cooperation Program of China [2013DFG02930]
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| 课题组名称 | LNM微结构计算力学（筹）
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| 论文分区 | 一类
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://dspace.imech.ac.cn/handle/311007/55326
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| 专题 | 非线性力学国家重点实验室
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| 通讯作者 | Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China. |
推荐引用方式
GB/T 7714 |
He XC,Lin M,Sha BY,et al. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension[J]. SCIENTIFIC REPORTS,2015,5:12808.
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| APA |
He XC.,Lin M.,Sha BY.,Feng SS.,Shi XH.,...&Qu, ZG .(2015).Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension.SCIENTIFIC REPORTS,5,12808.
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| MLA |
He XC,et al."Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension".SCIENTIFIC REPORTS 5(2015):12808.
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