Optimization of Ligand Surface Concentration for Biosensor based on Imaging Ellipsometry

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	Optimization of Ligand Surface Concentration for Biosensor based on Imaging Ellipsometry
	Niu Y(牛宇); Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
会议录名称	MICRO-AND NANOSYSTEMS IN MEDICINE, ACTIVE IMPLANTS, BIOSENSORS
	2009
会议名称	World Congress on Medical Physics and Biomedical Engineering
会议日期	SEP 07-12, 2009
会议地点	Munich, GERMANY
摘要	the biosensor based on imaging ellipsometry for bio-molecular interactions has been developed for more than ten years and used to several biological applications successfully, such as detection of five markers of Hepatitis B, tumor markers and virus infection. Ligand surface concentration which might be related with its spatial configuration and bioactivity is an important factor to affect the biosensor sensitivity and dynamic range. In this investigation, IgG and its corresponding antibody are selected as a couple of model molecules for the optimization of ligand surface concentration. The optimization result of ligand surface concentration is achieved by analyzing the surface concentration increase of antigen-antibody complex on sensing surface with various ligand surface concentrations.
WOS记录号	WOS:000291667000006
ISBN号	978-3-642-03886-0
收录类别	CPCI-S
语种	英语
引用统计
文献类型	会议论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/58883
专题	微重力重点实验室
通讯作者	Jin, G (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100080, Peoples R China.
推荐引用方式 GB/T 7714	Niu Y,Jin G,Jin, G . Optimization of Ligand Surface Concentration for Biosensor based on Imaging Ellipsometry[C]MICRO-AND NANOSYSTEMS IN MEDICINE, ACTIVE IMPLANTS, BIOSENSORS,2009.

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