Immune-microassay with optical proteinchip for protein detection

IMECH-IR > 力学所知识产出(1956-2008)

	Immune-microassay with optical proteinchip for protein detection
	Jin G(靳刚); Wang ZH; Qi C; Zhao ZY; Chen S(陈涉); Meng YH; Ying PQ; Xia LH; Wan LJ; Jin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China.
会议录名称	PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH
	2003
会议名称	25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
会议日期	SEP 17-21, 2003
会议地点	Cancun, MEXICO
摘要	An optical proteinchip upon antigen-antibody affinity and the chip analysis system have been used in immune analysis. The chip is processed with chip design, surface patterning, surface modification, ligand immobilization to form a microarray with many immune probes - one kind of antigen (or antibody) occupying one unit in the microarray and many such units in matrix. In micro-reactor of bio-molecule interaction, when ligand met its receptor, they would bind into bio-specific complex, which resulted in the thickness of the probe surface layer (surface concentration of antigen-antibody) increasing. The variation of protein pattern on the chip surface corresponding to the ligand immobilization and protein interactions was screened with optical imaging ellipsometry. A non-labeling micro-assay for protein detection was realized with antigen-antibody affinity and non-disturbance optical sampling, which was available for the direct test of crude samples, such as serum, etc. Some application results in immune analysis were presented also.
WOS记录号	WOS:000189395300931
ISBN号	0-7803-7789-3
收录类别	CPCI-S ; EI
语种	英语
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	会议论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/58930
专题	力学所知识产出(1956-2008)
通讯作者	Jin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China.
推荐引用方式 GB/T 7714	Jin G,Wang ZH,Qi C,et al. Immune-microassay with optical proteinchip for protein detection[C]PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH,2003.

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