IMECH-IR  > 力学所知识产出(1956-2008)
Immune-microassay with optical proteinchip for protein detection
Jin G(靳刚); Wang ZH; Qi C; Zhao ZY; Chen S(陈涉); Meng YH; Ying PQ; Xia LH; Wan LJ; Jin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China.
Source PublicationPROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH
2003
Conference Name25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Conference DateSEP 17-21, 2003
Conference PlaceCancun, MEXICO
AbstractAn optical proteinchip upon antigen-antibody affinity and the chip analysis system have been used in immune analysis. The chip is processed with chip design, surface patterning, surface modification, ligand immobilization to form a microarray with many immune probes - one kind of antigen (or antibody) occupying one unit in the microarray and many such units in matrix. In micro-reactor of bio-molecule interaction, when ligand met its receptor, they would bind into bio-specific complex, which resulted in the thickness of the probe surface layer (surface concentration of antigen-antibody) increasing. The variation of protein pattern on the chip surface corresponding to the ligand immobilization and protein interactions was screened with optical imaging ellipsometry. A non-labeling micro-assay for protein detection was realized with antigen-antibody affinity and non-disturbance optical sampling, which was available for the direct test of crude samples, such as serum, etc. Some application results in immune analysis were presented also.
WOS IDWOS:000189395300931
ISBN0-7803-7789-3
Indexed ByCPCI-S ; EI
Language英语
Citation statistics
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/58930
Collection力学所知识产出(1956-2008)
Corresponding AuthorJin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China.
Recommended Citation
GB/T 7714
Jin G,Wang ZH,Qi C,et al. Immune-microassay with optical proteinchip for protein detection[C]. NEW YORK:IEEE,2003.
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