The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels | |
Wang XL; Hao MD; Du X; Wang GQ; Matsushita J; Wang, XL (reprint author), Univ Sci & Technol Beijing, Sch Mech Engn, Beijing 100083, Peoples R China.; Wang, XL (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.; Wang, XL (reprint author), Chinese Acad Sci, Inst Mech, Lab Nonlinear Mech, Beijing 100190, Peoples R China. | |
发表期刊 | COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE |
2016 | |
页码 | 7819403 |
ISSN | 1748-670X |
摘要 | Bacteria can form biofilm streamers in microfluidic channels with various geometries. Experiments show that the streamer geometry, such as its shape or thickness, depends on the fluid velocity and the geometry and curvature of the microfluidic channel. In the paper, a mechanical analysis of the flow field is made in different channels, which shows that the secondary flow in the channel is the reason for streamer nucleation and that the shear stress distribution decides the streamer geometry including shape and thickness. Through a finite elements simulation, we obtain the secondary flow forming positions in both static and rotating channels: positions that are the location of nucleation of the streamer. Thick or wide biofilm streamers occur at the points of minimum shear stress in static channels. Furthermore, in rotating channels, spiral-like streamers form, due to the helical shape of the minimum shear stress distribution. The findings may allow the prevention of biofilm formation and also the removal of bacteria adhered onto certain surfaces in channels with small cross sections. The analysis also indicates how one can obtain desirable biofilm streamers by control of the channel geometry and the loading conditions. |
关键词 | Gradient Structure Strain Hardening Ductility Transformation-induced Plasticity Strain Partitioning |
DOI | 10.1155/2016/7819403 |
URL | 查看原文 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000377886400001 |
关键词[WOS] | Gradient structure ; Strain hardening ; Ductility ; Transformation-induced plasticity ; Strain partitioning |
WOS研究方向 | Mathematical & Computational Biology |
WOS类目 | Mathematical & Computational Biology |
项目资助者 | The work was supported by Harvard University, the National Natural Science Foundation of China (11272002), Beijing Education Young Elite Teacher Project (YETP0363), and Opening Fund of State Key Laboratory of Nonlinear Mechanics. |
论文分区 | Q4 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/59527 |
专题 | 非线性力学国家重点实验室 |
通讯作者 | Wang, XL (reprint author), Univ Sci & Technol Beijing, Sch Mech Engn, Beijing 100083, Peoples R China.; Wang, XL (reprint author), Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA.; Wang, XL (reprint author), Chinese Acad Sci, Inst Mech, Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
推荐引用方式 GB/T 7714 | Wang XL,Hao MD,Du X,et al. The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels[J]. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2016:7819403. |
APA | Wang XL.,Hao MD.,Du X.,Wang GQ.,Matsushita J.,...&Wang, XL .(2016).The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels.COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,7819403. |
MLA | Wang XL,et al."The Mechanical Analysis of the Biofilm Streamer Nucleation and Geometry Characterization in Microfluidic Channels".COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2016):7819403. |
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