| Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands |
| Li L(李龙); Hu JL; Shi XH(施兴华); Shao YF(邵颖峰); Song F(宋凡); Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mech, Beijing 100190, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Jiangsu, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.
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发表期刊 | SOFT MATTER
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| 2017-06-21
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卷号 | 13期号:23页码:4294-4304 |
ISSN | 1744-683X
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摘要 | Gaining insights into the binding of membrane-anchored receptors and ligands that mediate cell adhesion and signal transduction is of great significance for understanding numerous physiological processes driven by intercellular communication. Lipid rafts microdomains in cell membranes enriched in cholesterol and saturated lipids such as sphingomyelin are believed to serve as the essential platforms to recruit protein molecules for biological functions. An important question remains how the lipid rafts affect the binding constant of membrane-anchored receptors and ligands. We have investigated the adhesion of multicomponent membranes by using Monte Carlo simulations of a mesoscopic model with biologically relevant parameters. We find that the preferential partitioning of membrane-anchored receptor and ligand proteins in the lipid rafts significantly increases the binding constant of those proteins in cooperation with the shape fluctuations of the membranes caused by thermal excitations. The binding constant can even be greater than that of the same receptors and ligands anchored to two apposing supported planar membranes without shape fluctuations. The membrane shape fluctuations facilitate the binding of the anchored receptors and ligands in contrast to the case of homogeneous membranes. Our results suggest that cells might regulate the binding of membrane-anchored receptor and ligand proteins by modulating the properties of lipid rafts such as area fraction size and the affinity of rafts to the proteins. |
DOI | 10.1039/c7sm00572e
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收录类别 | SCI
; EI
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语种 | 英语
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WOS记录号 | WOS:000403433600012
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关键词[WOS] | 2-DIMENSIONAL DISSOCIATION-CONSTANT
; CELL-ADHESION MOLECULES
; LATERAL DIFFUSION
; CONTACT AREA
; CATCH BONDS
; KINETICS
; TCR
; INSIGHTS
; ROUGHNESS
; PROTEINS
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WOS研究方向 | Chemistry
; Materials Science
; Physics
; Polymer Science
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WOS类目 | Chemistry, Physical
; Materials Science, Multidisciplinary
; Physics, Multidisciplinary
; Polymer Science
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项目资助者 | National Natural Science Foundation of China(11472285
; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB22040102)
; National Key Research and Development Program of China(2016YFA0501601)
; Fundamental Research Funds for the Central Universities and Shenzhen Science and Technology Innovation Committee(JCYJ20160531151105346)
; 11232013
; 21504038)
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课题组名称 | LNM生物材料微结构和力学性能
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论文分区 | 一类
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力学所作者排名 | 1
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引用统计 |
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文献类型 | 期刊论文
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条目标识符 | http://dspace.imech.ac.cn/handle/311007/60527
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专题 | 非线性力学国家重点实验室
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通讯作者 | Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.; Song, F (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mech, Beijing 100190, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Jiangsu, Peoples R China.; Hu, JL (reprint author), Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China.; Song, F (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China. |
推荐引用方式 GB/T 7714 |
Li L,Hu JL,Shi XH,et al. Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands[J]. SOFT MATTER,2017,13,23,:4294-4304.
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APA |
李龙.,Hu JL.,施兴华.,邵颖峰.,宋凡.,...&Song, F .(2017).Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands.SOFT MATTER,13(23),4294-4304.
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MLA |
李龙,et al."Lipid rafts enhance the binding constant of membrane-anchored receptors and ligands".SOFT MATTER 13.23(2017):4294-4304.
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