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Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles
Tian, Fei; Zhang, Wei; Cai, Lili; Li, Shanshan; Hu GQ(胡国庆); Cong, Yulong; Liu, Chao; Li, Tiejun; Sun, Jiashu; Li, TJ (reprint author), Hebei Univ Technol, Sch Mech Engn, Tianjin 300401, Peoples R China.; Liu, C; Sun, JS (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China.; Sun, JS (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Source PublicationLAB ON A CHIP
2017-09-21
Volume17Issue:18Pages:3078-3085
ISSN1473-0197
Abstract

The microfluidic passive control of microparticles largely relies on the hydrodynamic effects of the carrier media such as Newtonian fluids and viscoelastic fluids. Yet the viscoelastic/Newtonian interfacial effect has been scarcely investigated, especially for high-resolution particle separation. Here we report a microfluidic co-flow of Newtonian (water or PBS) and viscoelastic fluids (PEO) for the size-dependent separation of microparticles. The co-flow condition generates a stable viscoelastic/Newtonian interface, giving rise to the wall-directed elastic lift forces that compete with the center-directed lift forces, and efficiently hinders the migration of microparticles from the Newtonian to the viscoelastic fluid in a size-dependent manner. An almost complete separation of a binary mixture of 1 mu m and 2 mu m polystyrene particles is achieved by the co-flow of water and a very dilute PEO solution (100 ppm), whereas the sole use of water or PEO could not lead to an efficient separation. This co-flow microfluidic system is also applied for the separation of Staphylococcus aureus (1 mu m) from platelets (2-3 mu m) with > 90% efficiencies and purities.

DOI10.1039/c7lc00671c
URL查看原文
Indexed BySCI
Language英语
WOS IDWOS:000410405600008
WOS KeywordVISCOSITY ELASTIC FLUIDS ; SPHERICAL-PARTICLES ; INERTIAL MIGRATION ; MOLECULAR-WEIGHT ; CELL-SEPARATION ; POISEUILLE FLOW ; RIGID SPHERES ; MICROCHANNELS ; FRACTIONATION ; BEHAVIOR
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
WOS SubjectBiochemical Research Methods ; Chemistry, Multidisciplinary ; Chemistry, Analytical ; Nanoscience & Nanotechnology
Funding OrganizationNSFC(21622503 ; Youth Innovation Promotion Association CAS(2016035) ; Beijing Municipal Science and Technology Commission(Z171100001117135 ; Joint Doctoral Training Foundation of HEBUT, Hebei in the Graduate Student Innovation Ability Training Project ; 21475028 ; Z161100004916095) ; 11572334)
DepartmentLNM微纳米流体力学
Classification一类
Ranking5
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/70057
Collection非线性力学国家重点实验室
Corresponding AuthorLi, TJ (reprint author), Hebei Univ Technol, Sch Mech Engn, Tianjin 300401, Peoples R China.; Liu, C; Sun, JS (reprint author), Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China.; Sun, JS (reprint author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
Recommended Citation
GB/T 7714
Tian, Fei,Zhang, Wei,Cai, Lili,et al. Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles[J]. LAB ON A CHIP,2017,17(18):3078-3085.
APA Tian, Fei.,Zhang, Wei.,Cai, Lili.,Li, Shanshan.,胡国庆.,...&Sun, JS .(2017).Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles.LAB ON A CHIP,17(18),3078-3085.
MLA Tian, Fei,et al."Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles".LAB ON A CHIP 17.18(2017):3078-3085.
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