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Cooperative wrapping of nanoparticles of various sizes and shapes by lipid membranes
Xiong K; Zhao JY; Yang DW; Cheng QW; Wang JL(王九令); Ji HB
Source PublicationSOFT MATTER
2017-07-14
Volume13Issue:26Pages:4644-4652
ISSN1744-683X
Abstract

Understanding the interaction between nanoparticles (NPs) and cell membranes is crucial for the design of NP-based drug delivery systems and for the assessment of the risks exerted by the NPs. Recent experimental and theoretical studies have shown that cell membranes can mediate attraction between NPs and form tubular structures to wrap multiple NPs. However, the cooperative wrapping process is still not well understood, and the shape effect of NPs is not considered. In this article, we use large-scale coarse-grained molecular dynamics (CGMD) simulations to study the cooperative wrapping of NPs when a varying number of NPs adhered to the membrane. Spherical, prolate and oblate NPs of different sizes are considered in this study. We find that, in addition to tubular structures, the membrane can form a pocket-like and a handle-like structure to wrap multiple NPs depending on the size and shape of the NPs. Furthermore, we find that NPs can mediate membrane hemifusion or fusion during this process. Our findings provide new insights into the interaction of NPs with the cell membrane.

DOI10.1039/c7sm00345e
URL查看原文
Indexed BySCI ; EI
Language英语
WOS IDWOS:000411436600011
WOS KeywordReceptor-mediated Endocytosis ; One-dimensional Nanomaterials ; Cellular Uptake ; Mammalian-cells ; Internalization ; Vesicles ; Fusion ; Penetration ; Particles ; Bilayer
WOS Research AreaChemistry ; Materials Science ; Physics ; Polymer Science
WOS SubjectChemistry, Physical ; Materials Science, Multidisciplinary ; Physics, Multidisciplinary ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China(41173113 ; Hundred Talents Program of Chinese Academy of Sciences ; 41473122)
Classification一类
Ranking1
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Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/70066
Collection非线性力学国家重点实验室
Corresponding AuthorWang JL(王九令); Ji HB
Recommended Citation
GB/T 7714
Xiong K,Zhao JY,Yang DW,et al. Cooperative wrapping of nanoparticles of various sizes and shapes by lipid membranes[J]. SOFT MATTER,2017,13(26):4644-4652.
APA Xiong K,Zhao JY,Yang DW,Cheng QW,Wang JL,&Ji HB.(2017).Cooperative wrapping of nanoparticles of various sizes and shapes by lipid membranes.SOFT MATTER,13(26),4644-4652.
MLA Xiong K,et al."Cooperative wrapping of nanoparticles of various sizes and shapes by lipid membranes".SOFT MATTER 13.26(2017):4644-4652.
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