Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks

doi:10.1063/1.5054800

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	Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks
	Jiang TY ; Ren YK ; Liu WY ; Tang DW ; Tao Y; Xue R ; Jiang HY
发表期刊	PHYSICS OF FLUIDS
	2018-11-01
卷号	30 期号:11 页码:Ar-112003
ISSN	1070-6631
摘要	In this study, we proposed a high-throughput separation strategy of the binary colloid mixture by dielectrophoresis (DEP) induced around large-scale bipolar electrode arrays embedded in microfabricated fluidic networks via a thorough numerical investigation. The usage of a floating electrode (FE) eliminates the need of external Ohmic connection to individual array units, therefore potentially steering the faddish design of new microdevice structures. Diffuse charge dynamics within the induced double layer at opposite ends of every FE permit a sinusoidal electric field to penetrate throughout the whole device, as long as the imposed field frequency is beyond the reciprocal resistor-capacitor time constant at the electrode/electrolyte interface. In this special device configuration, FEs interconnect multiple microchannels arranged in parallel. Pockets embedded on the sidewalls of fluidic channels help create strong field gradients at the tip of FEs and sharp pocket/channel junctions, improving the trapping performance of incoming bioparticles subjected to positive-DEP (pDEP) force, while latex beads experiencing negative-DEP (nDEP) stress are electrically squeezed to the midchannel and finally exit as a series of co-flowing thin streams with unequal translatory velocity. Taking the synergy of DEP force, induced-charge electro-osmosis, alternating-current electrothermal streaming, pressure-driven flow, and buoyancy effect into consideration, a numerical model is established to account for motion trajectories of micro-entities in full-scale three-dimensional space using the Lagrange particle track algorithm, as well as testing the feasibility of the device design in separation of the binary mixture containing yeast cells and polystyrene beads. Applying suitable voltage parameters of frequency O(1) MHz and electric field strength O(10) V/mm, highly efficient DEP separation is theoretically achievable under inlet flow velocity on the order of O(1) mm/s, where most of incoming yeasts are captured by pDEP within these five parallel branching channels, while polystyrene spheres are repelled by nDEP away from the FE array to form slim beams co-flowing into the outlet according to the calculation results. The microfluidic separation device exploiting the FE array offers great potential to build up scalable electrokinetic platforms for high-throughput on-chip sample treatment. Published by AIP Publishing.
DOI	10.1063/1.5054800
URL	查看原文
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000451733300009
关键词[WOS]	INDUCED-CHARGE ELECTROOSMOSIS ; PARTICLES ; FLOW ; CELLS ; ELECTROROTATION ; ELECTROKINETICS ; MICROELECTRODES ; FIELDS
WOS研究方向	Mechanics ; Physics, Fluids & Plasmas
WOS类目	Mechanics ; Physics
项目资助者	National Natural Science Foundation of China [11672095, 11702035, 11702075] ; Chang'an University Fundamental Research Funds for the Central Universities [310832171008, 300102328201, 300102328501] ; Shaanxi kefa (2018) [2018ZDCXL-GY-0504, 2018ZDCXL-GY-05-07-02, 9] ; State Key Laboratory of Robotics and System (HIT) [SKLRS201803B] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics
论文分区	一类/力学重要期刊
力学所作者排名	1
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/78151
专题	非线性力学国家重点实验室
作者单位	1.Harbin Inst Technol, State Key Lab Robot & Syst, West Da Zhi St 92, Harbin 150001, Heilongjiang, Peoples R China 2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China 3.Changan Univ, Sch Elect & Control Engn, Middle Sect Naner Huan Rd, Xian 710064, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Jiang TY,Ren YK,Liu WY,et al. Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks[J]. PHYSICS OF FLUIDS,2018,30,11,:Ar-112003.
APA	Jiang TY.,Ren YK.,Liu WY.,Tang DW.,Tao Y.,...&Jiang HY.(2018).Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks.PHYSICS OF FLUIDS,30(11),Ar-112003.
MLA	Jiang TY,et al."Dielectrophoretic separation with a floating-electrode array embedded in microfabricated fluidic networks".PHYSICS OF FLUIDS 30.11(2018):Ar-112003.

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