Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight | |
Moser D; Sun SJ(孙树津); Li N(李宁); Biere K; Hoerl M; Matzel S; Feuerecker M; Buchheim JI; Strewe C; Thiel CS; Gao YX(高宇欣); Wang CZ(王成之); Ullrich O; Long M(龙勉); Chouker A | |
发表期刊 | SCIENTIFIC REPORTS |
2019-08-02 | |
卷号 | 9页码:11 |
ISSN | 2045-2322 |
摘要 | Gravitational stress in general and microgravity (mu g) in particular are regarded as major stress factors responsible for immune system dysfunction in space. To assess the effects of alternating mu g and hypergravity (hyper-g) on immune cells, the attachment of peripheral blood mononuclear cells (PBMCs) to adhesion molecules under flow conditions and the antigen-induced immune activation in whole blood were investigated in parabolic flight (PF). In contrast to hyper-g (1.8 g) and control conditions (1 g), flow and rolling speed of PBMCs were moderately accelerated during mu g-periods which were accompanied by a clear reduction in rolling rate. Whole blood analyses revealed a "primed" state of monocytes after PF with potentiated antigen-induced pro-inflammatory cytokine responses. At the same time, concentrations of anti-inflammatory cytokines were increased and monocytes displayed a surface molecule pattern that indicated immunosuppression. The results suggest an immunologic counterbalance to avoid disproportionate immune responses. Understanding the interrelation of immune system impairing and enhancing effects under different gravitational conditions may support the design of countermeasures to mitigate immune deficiencies in space. |
DOI | 10.1038/s41598-019-47655-x |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000478575000063 |
论文分区 | 二类/Q1 |
力学所作者排名 | 1 |
RpAuthor | Long, M.(mlong@imech.ac.cn) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/79502 |
专题 | 微重力重点实验室 |
推荐引用方式 GB/T 7714 | Moser D,Sun SJ,Li N,et al. Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight[J]. SCIENTIFIC REPORTS,2019,9:11. |
APA | Moser D.,Sun SJ.,Li N.,Biere K.,Hoerl M.,...&Chouker A.(2019).Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight.SCIENTIFIC REPORTS,9,11. |
MLA | Moser D,et al."Cells' Flow and Immune Cell Priming under alternating g-forces in Parabolic Flight".SCIENTIFIC REPORTS 9(2019):11. |
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