Nanoparticle translocation across the lung surfactant film regulated by grafting polymers

doi:10.1039/c9nr09251j

IMECH-IR > 非线性力学国家重点实验室

	Nanoparticle translocation across the lung surfactant film regulated by grafting polymers
	Bai X(白轩)1,2,3 ; Li MJ(李木均)2,3 ; Hu GQ(胡国庆)1
通讯作者	Hu, Guoqing(ghu@zju.edu.cn)
发表期刊	NANOSCALE
	2020-02-14
卷号	12 期号:6 页码:3931-3940
ISSN	2040-3364
摘要	Nanoparticle-based pulmonary drug delivery has gained significant attention due to its ease of administration, increased bioavailability, and reduced side effects caused by a high systemic dosage. After being delivered into the deep lung, the inhaled nanoparticles first interact with the lung surfactant lining layer composed of phospholipids and surfactant proteins and then potentially cause the dysfunction of the lung surfactant. Conditioning the surface properties of nanoparticles with grafting polymers to avoid these side effects is of crucial importance to the efficiency and safety of pulmonary drug delivery. Herein, we perform coarse-grained molecular simulations to decipher the involved mechanism responsible for the translocation of the polymer-grafted Au nanoparticles across the lung surfactant film. The simulations illustrate that conditioning of the grafting polymers, including their length, terminal charge, and grafting density, can result in different translocation processes. Based on the energy analysis, we find that these discrepancies in translocation stem from the affinity of the nanoparticles with the lipid tails and heads and their contact with the proteins, which can be tuned by the surface polarity and surface charge of the nanoparticles. We further demonstrate that the interaction between the nanoparticles and the lung surfactant is related to the depletion of the lipids and proteins during translocation, which affects the surface tension of the surfactant film. The change in the surface tension in turn affects the nanoparticle translocation and the collapse of the surfactant film. These results can help understand the adverse effects of the nanoparticles on the lung surfactant film and provide guidance to the design of inhaled nanomedicines for improved permeability and targeting.
DOI	10.1039/c9nr09251j
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000515391000037
关键词[WOS]	PULMONARY SURFACTANT ; BIOPHYSICAL INHIBITION ; INTERFACIAL PROPERTIES ; SILICA NANOPARTICLES ; LIPID MONOLAYER ; DRUG-DELIVERY ; PROTEIN-B ; MEMBRANES ; DYNAMICS ; ADSORPTION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
资助项目	NSFC[11832017] ; NSFC[11572334] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-JSC036] ; CAS Strategic Priority Research Program[XDB22040403]
项目资助者	NSFC ; CAS Key Research Program of Frontier Sciences ; CAS Strategic Priority Research Program
论文分区	一类
力学所作者排名	1
RpAuthor	Hu, Guoqing
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/81554
专题	非线性力学国家重点实验室
作者单位	1.Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Zhejiang, Peoples R China; 2.Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Inst Mech, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Bai X,Li MJ,Hu GQ. Nanoparticle translocation across the lung surfactant film regulated by grafting polymers[J]. NANOSCALE,2020,12,6,:3931-3940.
APA	白轩,李木均,&胡国庆.(2020).Nanoparticle translocation across the lung surfactant film regulated by grafting polymers.NANOSCALE,12(6),3931-3940.
MLA	白轩,et al."Nanoparticle translocation across the lung surfactant film regulated by grafting polymers".NANOSCALE 12.6(2020):3931-3940.

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Jp2020031.pdf（8606KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载