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Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation
Wang, Tianhao1; Lv SQ(吕守芹)2,3; Hao, Yinjing1; Su, Zinan1; Long M(龙勉)2,3; Cui, Yuhong1
Corresponding AuthorLong, Mian(mlong@imech.ac.cn) ; Cui, Yuhong(yhcui@tju.edu.cn)
Source PublicationBIOPHYSICAL JOURNAL
2021-11-02
Volume120Issue:21Pages:4859-4873
ISSN0006-3495
AbstractHepatic sinusoids present complex anatomical structures such as the endothelial sieve pores and the Disse space, which govern the microscopic blood flow in the sinusoids and are associated with structural variations in liver fibrosis and cirrhosis. However, the contributions of the permeability of endothelial and collagen layers and the roughness of hepatocyte microvilli to the features of this microflow remain largely unknown. Here, an immersed boundary method coupled with a lattice Boltzmann method was adopted in an in vitro hepatic sinusoidal model, and flow field and erythrocyte deformation analyses were conducted by introducing three new source terms including permeability of the endothelial layer, resistance of hepatocyte micro-villi and collagen layers, and deformation of red blood cells (RBCs). Numerical calculations indicated that alterations in endothe-lial permeability could significantly affect the flow velocity and flow rate distributions in hepatic sinusoids. Interestingly, a biphasic regulating pattern of shear stress occurred simultaneously on the surface of hepatocytes and the lower side of endothelium, i.e., the shear stress increased with increased thickness of hepatocyte microvilli and collagen layer when the endothelial permeability was high but decreased with the increase of the thickness at low endothelial permeability. Additionally, this specified microflow manipulates typical RBC deformation inside the sinusoid, yielding one-third of the variation of deformable index with varied endo-thelial permeability. These simulations not only are consistent with experimental measurements using in vitro liver sinusoidal chip but also elaborate the contributions of endothelial and collagen layer permeability and wall roughness. Thus, our results provide a basis for further characterizing this microflow and understanding its effects on cellular migration and deformation in the hepatic sinusoids.
DOI10.1016/j.bpj.2021.09.020
Indexed BySCI ; EI
Language英语
WOS IDWOS:000716322100020
WOS KeywordENDOTHELIAL GLYCOCALYX ; LIQUID FLOW ; FIBROSIS
WOS Research AreaBiophysics
WOS SubjectBiophysics
Funding ProjectNational Natural Science Foundation of China[11972252] ; Frontier Science Key Project of Chinese Science Academy[QYZDJ-SSW-JSC018] ; Tianjin Natural Science Foundation[17JCYBJC29300]
Funding OrganizationNational Natural Science Foundation of China ; Frontier Science Key Project of Chinese Science Academy ; Tianjin Natural Science Foundation
Classification一类/力学重要期刊
Ranking1
ContributorLong, Mian ; Cui, Yuhong
Citation statistics
Document Type期刊论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/87955
Collection国家微重力实验室
Affiliation1.Tianjin Univ, Sch Mech Engn, Tianjin, Peoples R China;
2.Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing Key Lab Engn Construct & Mechanobiol, Key Lab Micrograv,Natl Micrograv Lab,Inst Mech, Beijing, Peoples R China;
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tianhao,Lv SQ,Hao, Yinjing,et al. Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation[J]. BIOPHYSICAL JOURNAL,2021,120(21):4859-4873.
APA Wang, Tianhao,吕守芹,Hao, Yinjing,Su, Zinan,龙勉,&Cui, Yuhong.(2021).Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation.BIOPHYSICAL JOURNAL,120(21),4859-4873.
MLA Wang, Tianhao,et al."Influence of microflow on hepatic sinusoid blood flow and red blood cell deformation".BIOPHYSICAL JOURNAL 120.21(2021):4859-4873.
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