Two dimensional measurements of receptor ligand interactions

doi:10.3389/fmolb.2023.1154074

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	Two dimensional measurements of receptor ligand interactions
	Zheng SJ(郑松杰); Zou M(邹敏); Shao YF(邵颖峰); Wu, Huaping 2; Wu, Helong 2; Wang XH(王小环)
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
	2023-02-17
卷号	10 页码:1154074
摘要	Gaining insight into the two dimensional receptor ligand interactions, which play a significant role in various pivotal biological processes such as immune response and cancer metastasis, will deepen our understanding of numerous physiological and pathological mechanisms and contribute to biomedical applications and drug design. A central issue involved is how to measure the in situ receptor ligand binding kinetics. Here, we review several representative mechanical based and fluorescence based methods, and briefly discuss the strengths and weaknesses for each method. In addition, we emphasize the great importance of the combination of experimental and computational methods in studying the receptor ligand interactions, and further studies should focus on the synergistic development of experimental and computational methods.
关键词	receptor ligand interaction binding kinetics kinetic on rate kinetic off rate binding affinity two dimensional measuring methods
DOI	10.3389/fmolb.2023.1154074
收录类别	SCI
语种	英语
WOS记录号	WOS:000943037100001
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
项目资助者	Programs in the National Natural Science Foundation of China [12232019]
论文分区	二类/Q1
力学所作者排名	1
RpAuthor	Wu, HP ; Wu, HL (corresponding author), Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China. ; Wang, XH (corresponding author), Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China.
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/91780
专题	非线性力学国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Mech, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 3.Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China 4.Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zheng SJ,Zou M,Shao YF,et al. Two dimensional measurements of receptor ligand interactions[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2023,10:1154074.
APA	郑松杰,邹敏,邵颖峰,Wu, Huaping,Wu, Helong,&王小环.(2023).Two dimensional measurements of receptor ligand interactions.FRONTIERS IN MOLECULAR BIOSCIENCES,10,1154074.
MLA	郑松杰,et al."Two dimensional measurements of receptor ligand interactions".FRONTIERS IN MOLECULAR BIOSCIENCES 10(2023):1154074.

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