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Dynamics of morphological changes for mitochondrial fission and fusion
Wang SQ(王世骐); Fu ZL(付长亮); Zhang Y(章燕); Chen Q; Long M(龙勉); Long M
Source PublicationScience China-Physics Mechanics & Astronomy
AbstractMitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, which depended on the time-dependent distribution of the mitochondrial volume and the fission and fusion rates. Parametric analysis was done for two typical volume distributions. One was Gamma distribution and the other was Gaussian distribution, derived from the measurements of volume distribution for individual mitochondria in a living cell and purified mitochondria in vitro. The predictions indicated that the survival probability strongly depended on morphological changes of individual mitochondria and was inversely correlated to the fission and fusion rates. This work provided a new insight into quantifying the mitochondrial dynamics via monitoring the evolution of the mitochondrial volume.
Indexed BySCI
WOS IDWOS:000276776100012
WOS Research AreaPhysics
WOS SubjectPhysics, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China [30730032, 10332060] ; National Key Basic Research Foundation of China [2006CB910303] ; National High Technology Research and Development Program of China [2007AA02Z306] ; Chinese Academy of Sciences [KJCX2-YW-L08]
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLong M
Recommended Citation
GB/T 7714
Wang SQ,Fu ZL,Zhang Y,et al. Dynamics of morphological changes for mitochondrial fission and fusion[J]. Science China-Physics Mechanics & Astronomy,2010,53(4):680-689.
APA 王世骐,付长亮,章燕,Chen Q,龙勉,&Long M.(2010).Dynamics of morphological changes for mitochondrial fission and fusion.Science China-Physics Mechanics & Astronomy,53(4),680-689.
MLA 王世骐,et al."Dynamics of morphological changes for mitochondrial fission and fusion".Science China-Physics Mechanics & Astronomy 53.4(2010):680-689.
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