Mechanomics: an emerging field between biology and biomechanics

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	Mechanomics: an emerging field between biology and biomechanics
	Wang JW; Lv DY(吕东媛); Mao DB(毛德斌); Long M(龙勉); Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
发表期刊	Protein & Cell
	2014-07
卷号	5 期号:7 页码:518-531
ISSN	1674-800X
摘要	Cells sense various in vivo mechanical stimuli, which initiate downstream signaling to mechanical forces. While a body of evidences is presented on the impact of limited mechanical regulators in past decades, the mechanisms how biomechanical responses globally affect cell function need to be addressed. Complexity and diversity of in vivo mechanical clues present distinct patterns of shear flow, tensile stretch, or mechanical compression with various parametric combination of its magnitude, duration, or frequency. Thus, it is required to understand, from the viewpoint of mechanobiology, what mechanical features of cells are, why mechanical properties are different among distinct cell types, and how forces are transduced to downstream biochemical signals. Meanwhile, those in vitro isolated mechanical stimuli are usually coupled together in vivo, suggesting that the different factors that are in effect individually could be canceled out or orchestrated with each other. Evidently, omics analysis, a powerful tool in the field of system biology, is advantageous to combine with mechanobiology and then to map the full-set of mechanically sensitive proteins and transcripts encoded by its genome. This new emerging field, namely mechanomics, makes it possible to elucidate the global responses under systematically-varied mechanical stimuli. This review discusses the current advances in the related fields of mechanomics and elaborates how cells sense external forces and activate the biological responses.
关键词	Mechanomics Mechanobiology Proteomics Transcriptomics
学科领域	Cell Biology
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000339333400005
项目资助者	This work was supported by National Basic Research Program (973 Program) (No. 2011CB710904), National Natural Science Foundation (No. 31110103918), Strategic Priority Research Program grants XDA01030102 and XDA04020219, and National High Technology Research and Development Program grant 2011AA020109, and Knowledge Innovation Program grant KJCX2-YW-L08.
课题组名称	NML分子-细胞生物力学与空间生命科学
论文分区	二类
引用统计	被引频次：52[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/49028
专题	微重力重点实验室
通讯作者	Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Wang JW,Lv DY,Mao DB,et al. Mechanomics: an emerging field between biology and biomechanics[J]. Protein & Cell,2014,5,7,:518-531.
APA	Wang JW,Lv DY,Mao DB,Long M,&Long, M .(2014).Mechanomics: an emerging field between biology and biomechanics.Protein & Cell,5(7),518-531.
MLA	Wang JW,et al."Mechanomics: an emerging field between biology and biomechanics".Protein & Cell 5.7(2014):518-531.

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