The mechano-biological coupling mechanism of cell response to altered gravity is crucial to understand physiological changes of astronauts in space microgravity environment and to develop relevant countermeasures. To address this issue, a novel space cell culture hardware mainly consisting of precisely controlled flow chamber and gas exchange unit is developed as an experimental payload in SJ-10 recoverable microgravity experimental satellite. Endothelial cells (ECs) and mesenchymal stem cells (MSCs) are cultured in the hardware during the SJ-10 mission, and recovered samples are analysed elaboratively. The results indicate that microgravity can suppress cellular metabolism. MSCs cultured with hepatic inducing medium are preferential in hepatic differentiation at long-term duration under microgravity. Both ECs and MSCs are regulated by microgravity and respond differentially in initiating cytoskeletal remodeling, or dysregulating signaling pathways relevant to cell adhesion, or directing hepatic differentiation.
Sun SJ,Wang CZ,Li N,et al. Cell Growth and Differentiation Under Microgravity[Ch]. Life Science in Space: Experiments on Board the SJ-10 Recoverable Satellite,Springer,2019.
; Wang CZ(王成之)
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