Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model | |
Zhou LW(周吕文)1,2,3; Feng SL(冯世亮)1,2,3; Li L(李龙)4,5; Lv SQ(吕守芹)2,3,6; Zhang Y(章燕)2,3,6; Long M(龙勉)2,3,6 | |
通讯作者 | Li, Long(lilong@lnm.imech.ac.cn) ; Long, Mian(mlong@imech.ac.cn) |
发表期刊 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY |
2021-11-17 | |
卷号 | 9页码:12 |
ISSN | 2296-634X |
摘要 | Many eukaryotic cells, including neutrophils and Dictyostelium cells, are able to undergo correlated random migration in the absence of directional cues while reacting to shallow gradients of chemoattractants with exquisite precision. Although progress has been made with regard to molecular identities, it remains elusive how molecular mechanics are integrated with cell mechanics to initiate and manipulate cell motility. Here, we propose a two dimensional (2D) cell migration model wherein a multilayered dynamic seesaw mechanism is accompanied by a mechanical strain-based inhibition mechanism. In biology, these two mechanisms can be mapped onto the biochemical feedback between phosphoinositides (PIs) and Rho GTPase and the mechanical interplay between filamin A (FLNa) and FilGAP. Cell migration and the accompanying morphological changes are demonstrated in numerical simulations using a particle-spring model, and the diffusion in the cell membrane are simulations using a one dimensional (1D) finite differences method (FDM). The fine balance established between endogenous signaling and a mechanically governed inactivation scheme ensures the endogenous cycle of self-organizing pseudopods, accounting for the correlated random migration. Furthermore, this model cell manifests directional and adaptable responses to shallow graded signaling, depending on the overwhelming effect of the graded stimuli guidance on strain-based inhibition. Finally, the model cell becomes trapped within an obstacle-ridden spatial region, manifesting a shuttle run for local explorations and can chemotactically "escape", illustrating again the balance required in the complementary signaling pathways. |
关键词 | chemotaxis cytoskeletal remodeling mathematical model biochemical biomechanical |
DOI | 10.3389/fcell.2021.786254 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000726135700001 |
关键词[WOS] | CELL-MIGRATION ; FOCAL ADHESIONS ; POLARIZATION ; NEUTROPHILS ; MECHANOSENSITIVITY ; MECHANISMS ; DYNAMICS ; RIGIDITY ; INSIGHTS ; POLARITY |
WOS研究方向 | Cell Biology ; Developmental Biology |
WOS类目 | Cell Biology ; Developmental Biology |
资助项目 | National Natural Science Foundation of China[12002176] ; National Natural Science Foundation of China[32130061] ; National Natural Science Foundation of China[11972200] ; National Natural Science Foundation of China[11902327] ; Opening fund of State Key Laboratory of Nonlinear Mechanics (LNM) of Chinese Academy of Sciences, Frontier Science Key Project of Chinese Science Academy[QYZDJ-SSW-JSC018] ; Youth Innovation Promotion Association CAS |
项目资助者 | National Natural Science Foundation of China ; Opening fund of State Key Laboratory of Nonlinear Mechanics (LNM) of Chinese Academy of Sciences, Frontier Science Key Project of Chinese Science Academy ; Youth Innovation Promotion Association CAS |
论文分区 | 一类 |
力学所作者排名 | 1 |
RpAuthor | Li, Long ; Long, Mian |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://dspace.imech.ac.cn/handle/311007/88062 |
专题 | 微重力重点实验室 非线性力学国家重点实验室 |
作者单位 | 1.Ningbo Univ, Sch Mech Engn & Mech, Smart Mat & Adv Struct Lab, Ningbo, Zhejiang, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Key Lab Micrograv, Beijing, Peoples R China; 3.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing Key Lab Engn Construct & Mechaobiol, Beijing, Peoples R China; 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing, Peoples R China; 5.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engineered Construct & Mechanobio, Beijing, Peoples R China; 6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou LW,Feng SL,Li L,et al. Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2021,9:12. |
APA | 周吕文,冯世亮,李龙,吕守芹,章燕,&龙勉.(2021).Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9,12. |
MLA | 周吕文,et al."Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021):12. |
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