Stretchable Electronic Facial Masks for Skin Electroporation

doi:10.1002/adfm.202311144

IMECH-IR > 非线性力学国家重点实验室

	Stretchable Electronic Facial Masks for Skin Electroporation
	Xu XK(徐新凯); Guo L(郭亮); Liu, Hao; Zhou ZX(周赞鑫); Li, Shuang; Gu, Qi; Ding, Shenglong; Guo, Haitao; Yan, Yan; Lan YQ(蓝昱群); Li QL(李沁蓝); Wei, Wanxin; Zhang, Jian; Liu C(刘崇); Su YW(苏业旺)
通讯作者	Su, Yewang(yewangsu@imech.ac.cn)
发表期刊	ADVANCED FUNCTIONAL MATERIALS
	2023-11-21
页码	14
ISSN	1616-301X
摘要	A stretchable electronic facial mask (SEFM) for skin electroporation by transdermal drug delivery is introduced. The SEFM exhibits characteristics of reusability, water-resistant, low cost, and portability. To achieve these objectives while maintaining satisfactory mechanical and electrical performance of the device, two main areas are innovated: (1) Grinding and doping modification of conductive ink to enhance its adhesion to silicone and increase conductivity through material research, as well as mechanical structure design for stretching stability of conductive ink electrodes. (2) Doping modification of high-temperature vulcanizes silicone to address the issue of increased resistance during encapsulation due to the swell of conductive ink. The SEFM designed with these innovations, is validated in rat experiments, demonstrating a 3-4 times increase in drug intake compared to the control group without skin electroporation. Safety is confirmed, and the promotion of niacinamide drug delivery is verified in human volunteers. The materials-modified conductive ink and conductive silicone proposed in SEFM can be employed in other flexible wearable devices, and this platform has the potential for future integration of additional components to achieve expanded functionality and productization. A stretchable electronic facial mask (SEFM) for skin electroporation by transdermal drug delivery, enabling the delivery of drugs such as sodium hyaluronate (SH), aloe powder, beta-glucose, and d-panthenol. The SEFM significantly enhances drug intake, with a 3-4 times increase. This platform holds the potential for future integration of additional components to expand its functionality and facilitate product development.image
关键词	conductive ink conductive silicone skin electroporation stretchable electronics
DOI	10.1002/adfm.202311144
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:001105679100001
关键词[WOS]	HUMAN STRATUM-CORNEUM ; HIGH-VOLTAGE ; TRANSPORT REGIONS ; ULTRASOUND ; MICRONEEDLES ; SILICONE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
资助项目	Y.S. gratefully acknowledges support from the National Natural Science Foundation of China (grant 12172359), Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-JSC014), and CAS Interdisciplinary Innovation Team (JCTD-2020[12172359] ; National Natural Science Foundation of China[ZDBS-LY-JSC014] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences[JCTD-2020-03] ; CAS Interdisciplinary Innovation Team
项目资助者	Y.S. gratefully acknowledges support from the National Natural Science Foundation of China (grant 12172359), Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (ZDBS-LY-JSC014), and CAS Interdisciplinary Innovation Team (JCTD-2020 ; National Natural Science Foundation of China ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences ; CAS Interdisciplinary Innovation Team
论文分区	一类
力学所作者排名	1
RpAuthor	Su, Yewang
引用统计
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/93494
专题	非线性力学国家重点实验室高温气体动力学国家重点实验室流固耦合系统力学重点实验室
推荐引用方式 GB/T 7714	Xu XK,Guo L,Liu, Hao,et al. Stretchable Electronic Facial Masks for Skin Electroporation[J]. ADVANCED FUNCTIONAL MATERIALS,2023:14.
APA	徐新凯.,郭亮.,Liu, Hao.,周赞鑫.,Li, Shuang.,...&苏业旺.(2023).Stretchable Electronic Facial Masks for Skin Electroporation.ADVANCED FUNCTIONAL MATERIALS,14.
MLA	徐新凯,et al."Stretchable Electronic Facial Masks for Skin Electroporation".ADVANCED FUNCTIONAL MATERIALS (2023):14.

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