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Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
作者:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  收藏  |  浏览/下载:385/108  |  提交时间:2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins* 期刊论文
CHINESE PHYSICS B, 2021, 卷号: 30, 期号: 3, 页码: 8
作者:  Lv SQ(吕守芹);  Ding QH(丁奇寒);  Zhang MK(张明坤);  Long M(龙勉)
Adobe PDF(834Kb)  |  收藏  |  浏览/下载:275/87  |  提交时间:2021/04/19
molecular dynamics simulations  mechanosensitive protein  allosteric dynamics  integrin  
Mechanically Regulated Outside-In Activation of an I-Domain-Containing Integrin 期刊论文
BIOPHYSICAL JOURNAL, 2020, 卷号: 119, 期号: 5, 页码: 966-977
作者:  Mao DB(毛德斌);  Lv SQ(吕守芹);  Zhang X(张潇);  Long M(龙勉)
Adobe PDF(2480Kb)  |  收藏  |  浏览/下载:240/65  |  提交时间:2020/10/29
Salt bridge interactions within the beta(2) integrin alpha(7) helix mediate force-induced binding and shear resistance ability 期刊论文
FEBS JOURNAL, 2018, 卷号: 285, 期号: 2, 页码: 261-274
作者:  Zhang X(张潇);  Li LD;  Li N(李宁);  Shu XY;  Zhou LW(周吕文);  Lv SQ(吕守芹);  Chen SB;  Mao DB;  Long M(龙勉)
Adobe PDF(2053Kb)  |  收藏  |  浏览/下载:247/67  |  提交时间:2018/10/30
beta(2) integrin  allostery  conformational stability  force  salt bridge interaction  
Dynamic contributions of P- and E-selectins to beta(2)-integrin-induced neutrophil transmigration 期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 1, 页码: 212-+
作者:  Gong YX;  Zhang Y(章燕);  Feng SL;  Liu XF;  Lv SQ(吕守芹);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.;  Long, M (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
Adobe PDF(2514Kb)  |  收藏  |  浏览/下载:593/248  |  提交时间:2017/04/26
Identification of the Conformational transition pathway in PIP2 Opening Kir Channels 期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5, 页码: 11289
作者:  Li JW;  Lv SQ(吕守芹);  Liu YZ;  Pang CL;  Chen YF;  Zhang SH;  Yu H;  Long M(龙勉);  Zhang HL;  Logothetis DE;  Zhan Y;  An HL;  An, HL (reprint author), Hebei Univ Technol, Inst Biophys, Sch Sci, Key Lab Mol Biophys, Tianjin 300401, Hebei Province, Peoples R China.
Adobe PDF(2141Kb)  |  收藏  |  浏览/下载:470/114  |  提交时间:2015/07/21
Mechanokinetics of receptor-ligand interactions in cell adhesion 期刊论文
Acta Mechanica Sinica, 2015, 卷号: 31, 期号: 2, 页码: 248-258
作者:  Li N(李宁);  Lv SQ(吕守芹);  Zhang Y(章燕);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Adobe PDF(809Kb)  |  收藏  |  浏览/下载:540/165  |  提交时间:2015/07/21
Receptor-ligand Interactions  Selectins  Beta(2) Integrins  2d Binding Kinetics  
Mechanochemistry of Single 2-Integrin-ICAM-1 Molecular Pair 会议论文
中国化学会第三届全国生物物理化学会议暨国际华人生物物理化学发展论坛, 中国山东青岛, 2014-07-23
作者:  Li N(李宁);  Mao DB(毛德斌);  Lv SQ(吕守芹);  Zhang Y(章燕);  Long M(龙勉)
浏览  |  Adobe PDF(387Kb)  |  收藏  |  浏览/下载:246/49  |  提交时间:2015/09/09
Integrin  Intercellular  Integrin  Adhesive  Governed  Rolling  Kinetics  Affinity  Subunit  Residues  
Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation 期刊论文
JOURNAL OF IMMUNOLOGY, 2013, 卷号: 190, 期号: 8, 页码: 4371-4381
作者:  Li N(李宁);  Mao DB(毛德斌);  Lv SQ(吕守芹);  Tong CF(佟春芳);  Zhang Y(章燕);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Key Lab Micrograv, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
Adobe PDF(777Kb)  |  收藏  |  浏览/下载:1415/360  |  提交时间:2013/05/21
The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphosphate-induced gating kinetics of Kir2 channels 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 50, 页码: 42278-42287
作者:  An HL;  Lv SQ(吕守芹);  Li JW;  Meng XY;  Zhan Y;  Cui M;  Long M(龙勉);  Zhang HL;  Logothetis DE;  Long, M;  Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Adobe PDF(2153Kb)  |  收藏  |  浏览/下载:1179/274  |  提交时间:2013/01/18
Rectifier K++ Channels  Beta-gamma-subunits  Potassium Channels  Crystal-structure  G-proteins  Structural Basis  Voltage-sensor  Pip2  Activation  Dynamics