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Mechanical strength determines Ca2+ transients triggered by the engagement of beta(2) integrins to their ligands 期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 387, 期号: 2, 页码: 7
作者:  Shu XY(舒芯钰);  Li N(李宁);  Huang DD(黄丹丹);  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1108Kb)  |  收藏  |  浏览/下载：438/164  |  提交时间：2020/04/07
beta(2) integrin  Ligands  Calcium transients  Bond strength  Mechanotransduction  Shear stress  
Binding of intercellular adhesion molecule 1 to beta(2)-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2018, 卷号: 315, 期号: 3, 页码: C409-C421
作者:  Tong CF(佟春芳);  Zhang Y(章燕);  Lv SQ(吕守芹);  Li N(李宁);  Gong YX(龚一心);  Yang H;  Feng SL;  Du Y;  Huang DD;  Long M(龙勉)
浏览  |  Adobe PDF(1593Kb)  |  收藏  |  浏览/下载：551/270  |  提交时间：2018/10/30
brain  ICAM-1  integrin  kinetics  liver  
Mechanical Strength and Structural Basis of beta(2) Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells: A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations 期刊论文
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2018, 卷号: 116, 期号: 2, 页码: 263-279
作者:  Li N(李宁);  Zhang X(张潇);  Li PW;  Yang H;  Tong CF;  Lv SQ(吕守芹);  Zhang Y(章燕);  Ye ZY;  Pan J;  Long M(龙勉)
浏览  |  Adobe PDF(865Kb)  |  收藏  |  浏览/下载：389/189  |  提交时间：2018/10/30
Liver sinusoidal endothelial cells  neutrophils  beta(2) integrin  shear flow  mechanical strength  
Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling 期刊论文
MOLECULAR BIOLOGY OF THE CELL, 2018, 卷号: 29, 期号: 4, 页码: 408-418
作者:  Li N(李宁);  Yang H(杨浩);  Wang ML;  Lv SQ(吕守芹);  Zhang Y(章燕);  Long M(龙勉)
浏览  |  Adobe PDF(1832Kb)  |  收藏  |  浏览/下载：403/95  |  提交时间：2018/10/30
Mechanokinetics of receptor-ligand interactions in cell adhesion 期刊论文
Acta Mechanica Sinica, 2015, 卷号: 31, 期号: 2, 页码: 248-258
作者:  Li N(李宁);  Lv SQ(吕守芹);  Zhang Y(章燕);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
浏览  |  Adobe PDF(809Kb)  |  收藏  |  浏览/下载：531/160  |  提交时间：2015/07/21
Receptor-ligand Interactions  Selectins  Beta(2) Integrins  2d Binding Kinetics  
The impact of N-terminal phosphorylation on LHCII conformation in state transition 期刊论文
Acta Mechanica Sinica, 2014, 卷号: 30, 期号: 3, 页码: 447-456
作者:  Ding JH(丁锦鸿);  Li N(李宁);  Wang ML;  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉);  Lu, SQ (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Key Lab Micrograv, Beijing 100190, Peoples R China.
浏览  |  Adobe PDF(746Kb)  |  收藏  |  浏览/下载：685/147  |  提交时间：2014/09/03
State Transition  Lhcii  Phosphorylation  Conformation  
Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation 期刊论文
JOURNAL OF IMMUNOLOGY, 2013, 卷号: 190, 期号: 8, 页码: 4371-4381
作者:  Li N(李宁);  Mao DB(毛德斌);  Lv SQ(吕守芹);  Tong CF(佟春芳);  Zhang Y(章燕);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Inst Mech, Natl Micrograv Lab, Key Lab Micrograv, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
Adobe PDF(777Kb)  |  收藏  |  浏览/下载：1406/355  |  提交时间：2013/05/21
Conformational Stability Analyses of Alpha Subunit I Domain of LFA-1 and Mac-1 期刊论文
PLOS One, 2011, 卷号: 6, 期号: 8, 页码: e24188
作者:  Mao DB(毛德斌);  Lv SQ(吕守芹);  Li N(李宁);  Zhang Y(章燕);  Long M(龙勉);  Mao, DB (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Beijing 100080, Peoples R China
Adobe PDF(818Kb)  |  收藏  |  浏览/下载：1275/289  |  提交时间：2012/04/01
A-domain  Molecular-dynamics  Structural Basis  Integrin Activation  Crystal-structure  Cell-adhesion  T-cell  Neutrophils  Affinity  Migration  
加载历史对低刚度下P-选择素-PSGL-1键寿命的影响 期刊论文
医用生物力学, 2009, 卷号: 24, 期号: 增刊1, 页码: 26-27
作者:  章燕;  孙淦云;  吕守芹;  李宁;  龙勉
Adobe PDF(126Kb)  |  收藏  |  浏览/下载：730/138  |  提交时间：2010/05/03
加载历史:5107  选择素:5028  低刚度:4013  寿命:3064  加载率:2582  配体分子:2236  蛋白质间相互作用:2231  受体:1907  调控因素:1243  炎症反应:1139  
Force spectroscopy of single receptor-ligand bond using an optical trap 会议论文
2009 Asia Communications and Photonics Conference and Exhibition, ACP 2009, Shanghai, China, November 2, 2009 - November 6, 2009
作者:  Zhang Y(章燕);  Sun GY(孙淦云);  Li N(李宁);  Huo B(霍波);  Lv SQ(吕守芹);  Long M(龙勉);  Zhang, Y.
浏览  |  Adobe PDF(2190Kb)  |  收藏  |  浏览/下载：110/36  |  提交时间：2017/07/14
Bond Dissociation  Force Spectroscopy  Low Loading  Novel Methods  Optical Trap  Receptor-ligand Bonds  Receptor-ligand Interactions  Thermal Fluctuations  Unbinding Transitions