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Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite
Li N(李宁)1,2; Wang CZ(王成之)1,2; Sun SJ(孙树津)1,2; Zhang C(张晨)1,2; Lv DY(吕东媛)1,2; Chen Q(陈琴)1,2; Long M(龙勉)1,2
2018-07-31
发表期刊FRONTIERS IN PHYSIOLOGY
卷号9页码:1025
ISSN1664-042X
摘要

Endothelial cells (ECs) are mechanosensitive cells undergoing morphological and functional changes in space. Ground based study has provided a body of evidences about how ECs can respond to the effect of simulated microgravity, however, these results need to be confirmed by spaceflight experiments in real microgravity. In this work, we cultured EA.hy926 ECs on board the SJ-10 Recoverable Scientific Satellite for 3 and 10 days, and analyzed the effects of space microgravity on the ECs. Space microgravity suppressed the glucose metabolism, modulated the expression of cellular adhesive molecules such as ICAM-1, VCAM-1, and CD44, and depressed the pro-angiogenesis and pro-inflammation cytokine secretion. Meanwhile, it also induced the depolymerization of actin filaments and microtubules, promoted the vimentin accumulation, restrained the collagen I and fibronectin deposition, regulated the mechanotransduction through focal adhesion kinase and Rho GTPases, and enhanced the exosome-mediated mRNA transfer. Unlike the effect of simulated microgravity, neither three dimensional growth nor enhanced nitric oxide production was observed in our experimental settings. This work furthers the understandings in the effects and mechanisms of space microgravity on ECs, and provides useful information for future spaceflight experimental design.

关键词Microgravity Sj-10 Satellite Endothelial Cells Adhesive Molecules Cytoskeleton Mechanotransduction Nitric Oxide Exosome Rna
DOI10.3389/fphys.2018.01025
收录类别SCI
语种英语
WOS记录号WOS:000440356600002
关键词[WOS]Simulated Microgravity ; 3-dimensional Growth ; Carcinoma-cells ; Hyaluronan-cd44 Interaction ; Microtubule Dynamics ; Actin Cytoskeleton ; Ionizing-radiation ; Icam-1 Expression ; Space Radiation ; Mammalian-cell
WOS研究方向Physiology
WOS类目Physiology
项目资助者National Natural Science Foundation of China(U1738115 ; Strategic Priority Research Program of Chinese Academy of Sciences(XDA04020202-19 ; Frontier Science Key Project of Chinese Academy of Sciences(XDA04020202-19 ; 31661143044) ; XDA04020416 ; XDA04020416 ; XDA04073800 ; XDA04073800 ; QYZDJ-SSW-JSC018) ; QYZDJ-SSW-JSC018)
论文分区二类/q1
力学所作者排名1
引用统计
文献类型期刊论文
条目标识符http://dspace.imech.ac.cn/handle/311007/77651
专题国家微重力实验室
通讯作者Long M(龙勉)
作者单位1.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Key Lab Micrograv,Natl Micrograv Lab,Ctr Biomech, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li N,Wang CZ,Sun SJ,et al. Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite[J]. FRONTIERS IN PHYSIOLOGY,2018,9:1025.
APA Li N.,Wang CZ.,Sun SJ.,Zhang C.,Lv DY.,...&Long M.(2018).Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite.FRONTIERS IN PHYSIOLOGY,9,1025.
MLA Li N,et al."Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite".FRONTIERS IN PHYSIOLOGY 9(2018):1025.
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