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FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration 期刊论文
BIOMATERIALS, 2024, 卷号: 305, 页码: 17
Authors:  Zhang XY(张晓宇);  Li PW(李培文);  Zhou J(周瑾);  Zhang ZL(张子良);  Wu H(吴欢);  Shu XY(舒芯钰);  Li W(李旺);  Wu Y(武亿);  Du Y(杜宇);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Favorite  |  View/Download：29/0  |  Submit date：2024/04/02
Liver sinusoidal endothelial cells  Fenestrae  Liver fibrosis  Cytoskeleton remodeling  FAK  MAPK  
Direct mechanical exposure initiates hepatocyte proliferation 期刊论文
JHEP REPORTS, 2023, 卷号: 5, 期号: 12, 页码: 13
Authors:  Li, Wang;  Wu Y(武亿);  Hu, Wenhui;  Zhou J(周瑾);  Shu XY(舒芯钰);  Zhang XY(张晓宇);  Zhang, Ziliang;  Wu, Huan;  Du, Yu;  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Adobe PDF(3334Kb)  |  Favorite  |  View/Download：71/4  |  Submit date：2024/01/02
Mechanotransduction  FAK  hepatic sinusoid chip  
Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis 期刊论文
SMALL, 2023, 卷号: 19, 期号: 2, 页码: 10.1002/smll.202204694
Authors:  Zhao, ChuanRong;  Li, Jingyi;  Jiang, ZhiTong;  Zhu, JuanJuan;  Zhao, JiaNan;  Yang, QianRu;  Yao, Weijuan;  Pang, Wei;  Li N(李宁);  Yu, Miaorong;  Gan, Yong;  Zhou, Jing
Adobe PDF(4465Kb)  |  Favorite  |  View/Download：258/94  |  Submit date：2022/12/20
atherosclerosis  decitabine  endothelial inflammation  hemodynamics  nanoparticles  
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer 期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
Authors:  Li N(李宁);  Zhang XY(张晓宇);  Zhou J(周瑾);  Li W(李旺);  Shu XY(舒芯钰);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(2553Kb)  |  Favorite  |  View/Download：362/107  |  Submit date：2022/10/23
Liver tissue stiffness  Shear stress  Hydrostatic pressure  Hepatocytes  Hepatocellular carcinoma  Liver sinusoidal endothelial cells  Hepatic stellate cells  Mechanotransduction pathways  Mechanomedicine  Drug design and delivery  
细胞力学2021年度研究进展 期刊论文
医用生物力学, 2022, 卷号: 37, 期号: 04, 页码: 584-590
Authors:  李宁;  龙勉
Adobe PDF(490Kb)  |  Favorite  |  View/Download：287/91  |  Submit date：2022/10/17
细胞力学  力学-生物学耦合  力学微环境  
力学微环境调控肝血窦内皮细胞表型维持与去分化 期刊论文
医用生物力学, 2021, 卷号: 36, 期号: S1, 页码: 302
Authors:  李宁;  李珮文;  张晓宇;  舒芯钰;  李旺;  吕守芹;  龙勉
Adobe PDF(2274Kb)  |  Favorite  |  View/Download：230/46  |  Submit date：2022/03/16
肝血窦内皮细胞  去分化  微环境  
基质硬度对肝血窦内皮细胞去窗孔化的调控机制 期刊论文
医用生物力学, 2021, 卷号: 36, 期号: S1, 页码: 275
Authors:  张晓宇;  李珮文;  周瑾;  李宁;  吕守芹;  龙勉
Adobe PDF(2167Kb)  |  Favorite  |  View/Download：213/49  |  Submit date：2022/03/16
基质硬度  肝血窦内皮细胞  肝纤维化  
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
Authors:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  Favorite  |  View/Download：408/116  |  Submit date：2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 卷号: 1864, 期号: 12, 页码: 9
Authors:  Li PW(李培文);  Zhou J(周瑾);  Li W(李旺);  Wu H(吴欢);  Hu JR(胡锦荣);  Ding QH(丁奇寒);  Lv SQ(吕守芹);  Pan J;  Zhang CY;  Li N(李宁);  Long M(龙勉)
Adobe PDF(4976Kb)  |  Favorite  |  View/Download：703/392  |  Submit date：2020/11/30
Liver sinusoidal endothelial cells  Fenestrae  Atomic force microscopy  Imaging recognition  Fully convolutional networks  Substrate stiffness  
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 卷号: 320, 期号: 3, 页码: G272-G282
Authors:  Li W(李旺);  Li PW(李培文);  Li N(李宁);  Du Y(杜宇);  Lv SQ(吕守芹);  Elad, David;  Long M(龙勉)
Adobe PDF(2812Kb)  |  Favorite  |  View/Download：212/105  |  Submit date：2022/10/25
hepatocytes  liver fibrosis  matrix stiffness  shear flow  three-dimensional liver sinusoidal model