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FAK-p38 signaling serves as a potential target for reverting matrix stiffness-modulated liver sinusoidal endothelial cell defenestration 期刊论文
BIOMATERIALS, 2024, 卷号: 305, 页码: 17
Authors:  Zhang XY(张晓宇);  Li PW(李培文);  Zhou J(周瑾);  Zhang ZL(张子良);  Wu H(吴欢);  Shu XY(舒芯钰);  Li W(李旺);  Wu Y(武亿);  Du Y(杜宇);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Favorite  |  View/Download：23/0  |  Submit date：2024/04/02
Liver sinusoidal endothelial cells  Fenestrae  Liver fibrosis  Cytoskeleton remodeling  FAK  MAPK  
Direct mechanical exposure initiates hepatocyte proliferation 期刊论文
JHEP REPORTS, 2023, 卷号: 5, 期号: 12, 页码: 13
Authors:  Li, Wang;  Wu Y(武亿);  Hu, Wenhui;  Zhou J(周瑾);  Shu XY(舒芯钰);  Zhang XY(张晓宇);  Zhang, Ziliang;  Wu, Huan;  Du, Yu;  Lv DY(吕东媛);  Lv SQ(吕守芹);  Li N(李宁);  Long M(龙勉)
Adobe PDF(3334Kb)  |  Favorite  |  View/Download：59/0  |  Submit date：2024/01/02
Mechanotransduction  FAK  hepatic sinusoid chip  
Biomechanics in liver regeneration after partial hepatectomy 期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023, 卷号: 11, 页码: 1165651
Authors:  Wu Y(武亿);  Li N(李宁);  Shu XY(舒芯钰);  Li W(李旺);  Zhang XY(张晓宇);  Lv DY(吕东媛);  Long M(龙勉)
Adobe PDF(2065Kb)  |  Favorite  |  View/Download：68/0  |  Submit date：2023/07/17
liver regeneration  partial hepatectomy  hemodynamics  mechanical loading  mechanotransduction  
Potential Roles of YAP/TAZ Mechanotransduction in Spaceflight-Induced Liver Dysfunction 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 3, 页码: 20
Authors:  Li W(李旺);  Shu XY(舒芯钰);  Zhang XY(张晓宇);  Zhang ZL(张子良);  Sun SJ(孙树津);  Li N(李宁);  Long M(龙勉)
Adobe PDF(1498Kb)  |  Favorite  |  View/Download：128/2  |  Submit date：2023/03/20
microgravity  liver metabolism  mechanosensing  cytoskeleton  nuclear deformation  phase separation  
Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 卷号: 1864, 期号: 12, 页码: 9
Authors:  Li PW(李培文);  Zhou J(周瑾);  Li W(李旺);  Wu H(吴欢);  Hu JR(胡锦荣);  Ding QH(丁奇寒);  Lv SQ(吕守芹);  Pan J;  Zhang CY;  Li N(李宁);  Long M(龙勉)
Adobe PDF(4976Kb)  |  Favorite  |  View/Download：683/386  |  Submit date：2020/11/30
Liver sinusoidal endothelial cells  Fenestrae  Atomic force microscopy  Imaging recognition  Fully convolutional networks  Substrate stiffness  
Mechanical strength determines Ca2+ transients triggered by the engagement of beta(2) integrins to their ligands 期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 387, 期号: 2, 页码: 7
Authors:  Shu XY(舒芯钰);  Li N(李宁);  Huang DD(黄丹丹);  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉)
View  |  Adobe PDF(1108Kb)  |  Favorite  |  View/Download：479/178  |  Submit date：2020/04/07
beta(2) integrin  Ligands  Calcium transients  Bond strength  Mechanotransduction  Shear stress  
Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite 期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 3, 页码: 4273-4286
Authors:  Lv DY(吕东媛);  Sun SJ(孙树津);  Zhang F(张帆);  Luo CH(罗春花);  Zheng L;  Wu Y(武毅);  Li N(李宁);  Zhang C;  Wang CZ;  Chen Q;  Long M(龙勉)
View  |  Adobe PDF(3477Kb)  |  Favorite  |  View/Download：316/99  |  Submit date：2019/04/11
mesenchymal stem cells  mechanotransduction  hepatocyte  signaling pathway  
Binding of intercellular adhesion molecule 1 to beta(2)-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2018, 卷号: 315, 期号: 3, 页码: C409-C421
Authors:  Tong CF(佟春芳);  Zhang Y(章燕);  Lv SQ(吕守芹);  Li N(李宁);  Gong YX(龚一心);  Yang H;  Feng SL;  Du Y;  Huang DD;  Long M(龙勉)
View  |  Adobe PDF(1593Kb)  |  Favorite  |  View/Download：570/276  |  Submit date：2018/10/30
brain  ICAM-1  integrin  kinetics  liver  
整合素LFA-1/Mac-1与不同配体相互作用的反应动力学及力谱差异 会议论文
第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议会议, 中国陕西西安, 2018年8月17日至21日
Authors:  李宁;  杨浩;  毛德斌;  王曼柳;  吕守芹;  章燕;  龙勉
View  |  Adobe PDF(163Kb)  |  Favorite  |  View/Download：247/40  |  Submit date：2019/11/21
Mac  LFA-1/Mac-1  反应动力学  PMN  整合素  
Mechanical Strength and Structural Basis of beta(2) Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells: A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations 期刊论文
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2018, 卷号: 116, 期号: 2, 页码: 263-279
Authors:  Li N(李宁);  Zhang X(张潇);  Li PW;  Yang H;  Tong CF;  Lv SQ(吕守芹);  Zhang Y(章燕);  Ye ZY;  Pan J;  Long M(龙勉)
View  |  Adobe PDF(865Kb)  |  Favorite  |  View/Download：412/195  |  Submit date：2018/10/30
Liver sinusoidal endothelial cells  neutrophils  beta(2) integrin  shear flow  mechanical strength