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Gravity-Vector Induces Mechanical Remodeling of rMSCs via Combined Substrate Stiffness and Orientation 期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 9, 页码: 14
Authors:  Zhang C(张晨);  Lv DY(吕东媛);  Zhang F(张帆);  Wu Y(武亿);  Zheng L(郑鲁);  Zhang XY(张晓宇);  Li Z(李展);  Sun SJ(孙树津);  龙勉Mian
Adobe PDF(3580Kb)  |  Favorite  |  View/Download:182/59  |  Submit date:2022/05/17
substrate stiffness  orientation  mechanosensing  nucleus translocation  cytoskeletal remodeling  focal adhesion complex reorganization  cellular morphology  
Hepatic differentiation of human embryonic stem cells by coupling substrate stiffness and microtopography 期刊论文
BIOMATERIALS SCIENCE, 2021, 页码: 15
Authors:  Luo CH(罗春花);  Lv DY(吕东媛);  Zheng L(郑鲁);  Zhang F(张帆);  Zhang X(张潇);  Lv SQ(吕守芹);  Zhang C(张晨);  Jia Xiaohua;  Shu XY(舒芯钰);  Li PW(李培文);  Li Z(李展);  Long M(龙勉)
Adobe PDF(7505Kb)  |  Favorite  |  View/Download:325/170  |  Submit date:2021/05/17
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
Authors:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  Favorite  |  View/Download:417/116  |  Submit date:2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Mechanomics analysis of hESCs under combined mechanical shear, stretch, and compression 期刊论文
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2020, 页码: 18
Authors:  Zhang F(张帆);  Wang JW(王家文);  Lv DY(吕东媛);  Zheng L(郑璐);  Shang GB(上官冰);  Gao YX(高宇欣);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(8050Kb)  |  Favorite  |  View/Download:333/179  |  Submit date:2020/10/23
Mechanomics  hESCs  iTRAQ  GSEA  WGCNA  
Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation 期刊论文
STEM CELL RESEARCH & THERAPY, 2019, 卷号: 10, 期号: 1, 页码: 16
Authors:  Wang JW(王家文);  Wu Y(武亿);  Zhang X(张潇);  Zhang F(张帆);  Lv DY(吕东媛);  Shang GB(上官冰);  Gao YX(高宇欣);  Long M(龙勉)
View  |  Adobe PDF(2406Kb)  |  Favorite  |  View/Download:235/73  |  Submit date:2020/03/11
Embryonic stem cell  Fluid shear mechanomics  Nuclear spreading  Histone acetylation  Chromatin decondensation  
Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite 期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 3, 页码: 4273-4286
Authors:  Lv DY(吕东媛);  Sun SJ(孙树津);  Zhang F(张帆);  Luo CH(罗春花);  Zheng L;  Wu Y(武毅);  Li N(李宁);  Zhang C;  Wang CZ;  Chen Q;  Long M(龙勉)
View  |  Adobe PDF(3477Kb)  |  Favorite  |  View/Download:327/101  |  Submit date:2019/04/11
mesenchymal stem cells  mechanotransduction  hepatocyte  signaling pathway  
Mechanical remodeling of normally sized mammalian cells under a gravity vector 期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 2, 页码: 802-813
Authors:  Zhang C;  Zhou LW(周吕文);  Zhang F(张帆);  Lv DY(吕东媛);  Li N(李宁);  Zheng L;  Xu YH(徐艳红);  Li Z;  Sun SJ(孙树津);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Inst Mech, 15 North 4th Ring Rd, Beijing 100190, Peoples R China.
View  |  Adobe PDF(3686Kb)  |  Favorite  |  View/Download:515/163  |  Submit date:2017/07/24
Gravity-directed  Mechanosensing  Nucleus Translocation  Cytoskeletal Remodeling  Fac Reorganization  
Mechanomics: an emerging field between biology and biomechanics 期刊论文
Protein & Cell, 2014, 卷号: 5, 期号: 7, 页码: 518-531
Authors:  Wang JW;  Lv DY(吕东媛);  Mao DB(毛德斌);  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
View  |  Adobe PDF(587Kb)  |  Favorite  |  View/Download:716/245  |  Submit date:2014/09/03
Mechanomics  Mechanobiology  Proteomics  Transcriptomics  
Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography 期刊论文
BIOMATERIALS, 2014, 卷号: 35, 期号: 13, 页码: 3945-3955
Authors:  Lv DY(吕东媛);  Luo CH;  Zhang C;  Li Z;  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
View  |  Adobe PDF(3274Kb)  |  Favorite  |  View/Download:1156/391  |  Submit date:2014/06/05
Stiffness  Topography  Stem Cell  Sternness  Morphology  
Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells 期刊论文
BIOMATERIALS, 2013, 卷号: 34, 期号: 31, 页码: 7616-7625
Authors:  Li Z(李展);  Gong YW(宫元卫);  Sun SJ(孙树津);  Du Y(杜宇);  Lv DY(吕东媛);  Liu XF(刘晓锋);  Long M(龙勉);  Sun, SJ (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
Adobe PDF(1994Kb)  |  Favorite  |  View/Download:1958/767  |  Submit date:2013/09/27
Stiffness  Topography  Dimension  Stem Cell  Proliferation  Differentiation