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Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis 期刊论文
BIOACTIVE MATERIALS, 2022, 卷号: 17, 页码: 406-424
作者:  Wang, Jin;  Xie, Si-an;  Li N(李宁);  Zhang, Tao;  Yao, Weijuan;  Zhao, Hucheng;  Pang, Wei;  Han, Lili;  Liu, Jiayu;  Zhou, Jing
Adobe PDF(21819Kb)  |  收藏  |  浏览/下载：272/23  |  提交时间：2022/06/10
Matrix stiffness  Inflammation  DDR1  DNMT1  Mechanotransduction  
Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer 期刊论文
ADVANCED DRUG DELIVERY REVIEWS, 2022, 卷号: 188, 页码: 114448
作者:  Li N(李宁);  Zhang XY(张晓宇);  Zhou J(周瑾);  Li W(李旺);  Shu XY(舒芯钰);  Wu Y(武亿);  Long M(龙勉)
Adobe PDF(2553Kb)  |  收藏  |  浏览/下载：321/90  |  提交时间：2022/10/23
Liver tissue stiffness  Shear stress  Hydrostatic pressure  Hepatocytes  Hepatocellular carcinoma  Liver sinusoidal endothelial cells  Hepatic stellate cells  Mechanotransduction pathways  Mechanomedicine  Drug design and delivery  
Gravity-Vector Induces Mechanical Remodeling of rMSCs via Combined Substrate Stiffness and Orientation 期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 9, 页码: 14
作者:  Zhang C(张晨);  Lv DY(吕东媛);  Zhang F(张帆);  Wu Y(武亿);  Zheng L(郑鲁);  Zhang XY(张晓宇);  Li Z(李展);  Sun SJ(孙树津);  龙勉Mian
Adobe PDF(3580Kb)  |  收藏  |  浏览/下载：149/46  |  提交时间：2022/05/17
substrate stiffness  orientation  mechanosensing  nucleus translocation  cytoskeletal remodeling  focal adhesion complex reorganization  cellular morphology  
Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli 期刊论文
ACTA MECHANICA SINICA, 2021, 页码: 17
作者:  Shu XY(舒芯钰);  Li N(李宁);  Wu Y(武亿);  Li W(李旺);  Zhang XY(张晓宇);  Li PW(李培文);  Lv DY(吕东媛);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(1359Kb)  |  收藏  |  浏览/下载：368/101  |  提交时间：2021/05/06
Liver sinusoidal endothelial cell  Shear stress  Mechanical stretch  Extracellular matrix  Stiffness  
Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning 期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2020, 卷号: 1864, 期号: 12, 页码: 9
作者:  Li PW(李培文);  Zhou J(周瑾);  Li W(李旺);  Wu H(吴欢);  Hu JR(胡锦荣);  Ding QH(丁奇寒);  Lv SQ(吕守芹);  Pan J;  Zhang CY;  Li N(李宁);  Long M(龙勉)
Adobe PDF(4976Kb)  |  收藏  |  浏览/下载：645/374  |  提交时间：2020/11/30
Liver sinusoidal endothelial cells  Fenestrae  Atomic force microscopy  Imaging recognition  Fully convolutional networks  Substrate stiffness  
Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model 期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2020, 卷号: 320, 期号: 3, 页码: G272-G282
作者:  Li W(李旺);  Li PW(李培文);  Li N(李宁);  Du Y(杜宇);  Lv SQ(吕守芹);  Elad, David;  Long M(龙勉)
Adobe PDF(2812Kb)  |  收藏  |  浏览/下载：175/85  |  提交时间：2022/10/25
hepatocytes  liver fibrosis  matrix stiffness  shear flow  three-dimensional liver sinusoidal model  
Regulation of morphology and differentiation of embryonic stem cells by substrate stiffness and topography 会议论文
中国生理学会基质生物学专业委员会第四次全国基质生物学学术会议, 中国江苏常州, 2019-06-27
作者:  Lv DY(吕东媛)
Adobe PDF(138Kb)  |  收藏  |  浏览/下载：269/43  |  提交时间：2020/09/28
Regulation of morphology and differentiation of embryonic stem cells by substrate stiffness and topography  
Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography 期刊论文
BIOMATERIALS, 2014, 卷号: 35, 期号: 13, 页码: 3945-3955
作者:  Lv DY(吕东媛);  Luo CH;  Zhang C;  Li Z;  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
Adobe PDF(3274Kb)  |  收藏  |  浏览/下载：1086/383  |  提交时间：2014/06/05
Stiffness  Topography  Stem Cell  Sternness  Morphology  
Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells 期刊论文
BIOMATERIALS, 2013, 卷号: 34, 期号: 31, 页码: 7616-7625
作者:  Li Z(李展);  Gong YW(宫元卫);  Sun SJ(孙树津);  Du Y(杜宇);  Lv DY(吕东媛);  Liu XF(刘晓锋);  Long M(龙勉);  Sun, SJ (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing 100190, Peoples R China.
Adobe PDF(1994Kb)  |  收藏  |  浏览/下载：1907/749  |  提交时间：2013/09/27
Stiffness  Topography  Dimension  Stem Cell  Proliferation  Differentiation  
Spring constant regulate selectin-ligand bond dissociation 会议论文
第五届中美生物医学工程暨海内外生物力学学术研讨会, 中国北京/Beijing, China, 2013-08-01
作者:  Zhang Y(章燕);  Sun GY(孙淦云);  Lv SQ(吕守芹);  Long M(龙勉)
Adobe PDF(91Kb)  |  收藏  |  浏览/下载：475/117  |  提交时间：2014/04/02
Dissociation  Regulate  Selectin  Constant  Formation  Further  Increased  Stiffness  Lifetime  Ligand  Binding  Assay  Probe  Force  Kinetics  Mainly  Reverse  Values  Well  Found